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LHCGR gene polymorphisms do not appear to be a major causative factor for the relatively low concentration of LH in patients with non-classic central precocious puberty.
rs13405728, rs4539842, and rs2293275 SNPs in LHCGR may contribute to the pathogenesis of polycystic ovary syndrome and could be used as potential biomarkers to predict the risk of disease (Meta-Analysis)
GWAS for neovascular age-related macular degeneration bilaterality found new genetic loci STON1-GTF2A1L/LHCGR/FSHR
The H3.3-PC4 interaction is essential for transcriptional activation and expression of the LHR gene.
the hCG-hyperglycosylated is functionally similar to hCG, although it has lower potency for LHCGR activation.
This study has evaluated the insLQ polymorphism in LHR in relation to potential associations with hormonal characteristics of human small antral follicles.
This study demonstrates that both gonadotrophin receptors9 FSH receptor (FSHR) and LH/choriogonadotrophin receptor (LHCGR) are expressed along the glandular epithelium of endometria and they mediate the effects of gonadotrophins on intracellular functions.
Genotyping analysis showed no association between luteinizing hormone receptor (LHCGR) rs68073206 and male infertility, however, this polymorphism was significantly associated with testosterone levels in normozoospermic subjects.
Data suggest that, during follicle maturation, levels of MIR122 determine levels of LHR mRNA expression in the ovary. (LHR = luteinizing hormone receptor; MIR122 = microRNA 122) [REVIEW]
genetic association/pharmacogenetic studies in population in India: Data suggest that need for (and dose required of) fertility agent recombinant LH in addition to fertility agent recombinant FSH is associated with SNP in LHCGR in women undergoing ovarian stimulation in conjunction with in vitro fertilization. (LH = luteinizing hormone; FSH = follicle stimulating hormone)
hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development
The reduced fertilisation and pregnancy rate was associated with a lower LH receptor density and a lack of essential down-regulation of the FSH and LH receptor.
This work demonstrates that the expression of FSHR and LHCGR can be induced in hGL5 cells but that the FSHR-dependent cAMP/PKA pathway is constitutively silenced, possibly to protect cells from FSHR-cAMP-PKA-induced apoptosis.
Inactivating mutations of the LHCGR gene may be a common cause of 46,XY primary amenorrhea.
data demonstrate that the majority of LHR mutations lead to intracellular retention and highlight the potential for novel pharmacological chaperone therapeutics that can "rescue" expression/function of retained mutant GPCRs.
expression and activation of LHCGR and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR internalization is unaltered
We showed that GNRHR and LHCGR were highly expressed in some wildtype aldosterone-producing adenoma samples, and that they positively correlated with GnRH-stimulated aldosterone production.
Mutation in the LHCGR gene is associated with Testotoxicosis.
The luteinizing hormone/human chorionic gonadotrophin receptor (LHCGR) variant N312S and the follicle-stimulating hormone receptor (FSHR) variant N680S can be utilized for the prediction of pregnancy chances in women undergoing IVF.
Data indicate two patients with peripheral precocious puberty and an activating mutation in the luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene.
Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice
Activating mutations in LHCGR cause familial male-limited precocious puberty
Study tested for the first time a role of ZFP36L2 in the decay of LHR mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR mRNA expression is controlled post-transcriptionally by ZFP36L2.
FSHR and LHR proteins are significantly upregulated in CCs surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence.
Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR
Data suggest that persistent cAMP signals from internalized luteinizing hormone receptor (LH receptors) contribute to transmitting LH effects inside follicle cells and ultimately to the oocyte.
Demonstrate the presence of LH receptors. Activation resulted in a dose-dependent increase in glucose-induced release of insulin.
LHCGR signaling in regulating the Ahr message involves protein kinase A pathway and is attributable to decreased transcription rate.
Data from mutant mouse strain (gain-of-function mutation in LHR, D578G; most common mutation found in familial male-limited precocious puberty) confirm that LHR is critical for male steroidogenesis, gametogenesis, and Leydig cell development.
LH/hCG tightly up-regulates MKP-3 which in turn, dephosphorylates ERK1/2 and drives p21 expression.
Data suggest that Lhcgr in endometrium and luteinizing hormone in blastocyst are involved in embryo/blastocyst implantation; expression of Lhcgr is up-regulated in endometrial epithelium in estrus cycle at time of implantation readiness (estrus).
Through the LHR, LH/hCG tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 by 8Br-cAMP.
Expression of LH receptor in nonpregnant mouse endometrium.
Testicular CYP1B1 expression is regulated by LH through a PRKA-mediated pathway.
Positive immunoreaction for LH receptors was present in the nuclei of urethral epithelium and endothelial cells of cavernous spaces in the corpus cavernosum and corpus spongiosum penis.
Role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice.
The study provides the first in vivo evidence linking the LH receptor, the EGFR, and ERK1/2 as sequential components of a pathway that regulates ovarian Cyp19a1 expression.
Diminution of Abeta accumulation in the absence of LH receptor supports the contention that dysregulation of LH may impact the pathogenesis of Alzheimer disease.
review of studies of Lhr expression and function using transgenic and knockout mouse models, including function as promoters of tumors
review of knockout mice studies of the effect of inactivation of Lhr on phenotype
large numbers of unknown LH-regulated granulosa cell genes are identified and their putative roles in ovarian function, are reported.
Gene expression of granulosa cells reveals that 747 transcripts are potentially regulated by LH.
The outcomes of the present study support a dynamic multi-facetted regulation of LHR during pre-translation.
expression of LHR mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP mRNA after the expected time of deviation may contribute to greater expression of LHR in the bovine dominant follicle
These results suggested an acute regulation of INSL3 by luteinizing hormone (LH) because INSL3 concentrations increased immediately after endogenous and exogenous LH stimulation.
INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
LHCGR mRNA expression in granulosa cells was significantly higher in large antral follicles than in cysts, and not detected in granulosa cells of small and medium antral follicles.
The luteinizing hormone receptor [LHR] splicing pattern is complex in bovine Leydig cells, and expression of full-length LHR and isoforms A and B changes when induced with LH.
Significant correlations were found between sperm quality parameters and polymorphisms in the luteinizing hromoe receptor gene in Chinese Holstein bulls.
The LHCGR gene is a potential marker for superovulation response and can be used to predict the most appropriate dose of FSH for superovulation in Chinese Holstein cows.
Dominant follicles experience a reduction in FSH dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH milieu of follicular waves.
Three single nucleotide polymorphisms in LHCGR were significantly associated with variations in cattle fertility and production traits.
Granulosa cells do not acquire functional LHR until follicle dominance occurs.
Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR and FSHR genes, respectively), but no significant effects were observed for the genes studied (
Differential expression of LHRH-receptor in bovine nasal tissue and its role in deslorelin delivery
Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr) resulted in infertile males
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr.
In porcine ovaries, MAb found 6 distinct LHR bands migrating at approximately 92, 80, 68, 59, 52 & 48 kDa. There is a possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders & Alzheimer's disease.
The N23-glycosylation site of the eLHCGR is not required for the functional coupling of the receptor with the cAMP pathway and is not responsible for the limited potency of eCG relative to pLH to activate this receptor.
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.
, lutropin-choriogonadotropic hormone receptor
, lutropin/choriogonadotropin receptor
, luteinizing hormone receptor
, LH receptor
, luteinizing hormone receptor 2 protein
, luteinizing hormone receptor precursor variant 1
, luteinizing hormone receptor precursor variant 2
, lutropin-choriogonadotropin receptor
, luteinizing hormone/choriogonadotropin receptor
, lutropin-choriogonadotropic hormone receptor-like