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the role of Muc4 in driving intestinal inflammation and inflammation-associated tumorigenesis
Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (show SLC13A2 Proteins) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.
Using the Pdx1 (show PDX1 Proteins)-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesions induced by mutated hK-ras is correlated with the ERK (show EPHB2 Proteins), JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling pathways.
Data show that Muc4 is upregulated and interacts with erbB2 (show ERBB2 Proteins) in gallbladders from BK5.erbB2 (show ERBB2 Proteins) mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 (show ERBB2 Proteins) signaling.
This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 (show LCN2 Proteins) and its clinical significance for prognosis of pancreatic cancer.
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
ErbB2 (show ERBB2 Proteins) and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells
As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels
MUC4 is regulated at the transcriptional level by CDX-1 (show CDX1 Proteins) and -2, HNF-1 alpha (show HNF1A Proteins) and -1 beta, FOXA1 (show FOXA1 Proteins)/A2, HNF-4 alpha (show HNF4A Proteins) and -4 gamma, and GATA-4 (show GATA4 Proteins), -5, and -6 factors in a cell-specific manner
the expression of mucins 1 to 4 and trefoil factor 3 (show TFF3 Proteins) was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
MUC4/X facilitated pancreatic cancer (PC) tumorigenesis via integrin-beta1/FAK (show PTK2 Proteins)/ERK (show EPHB2 Proteins) signaling pathway. Overall, these findings revealed the novel role of MUC4/X in promoting and sustaining the oncogenic features of PC.
auranofin could regulate the Her2 (show ERBB2 Proteins)/Akt (show AKT1 Proteins)/FOXO3 (show FOXO3 Proteins) signaling pathway in SKOV3 cells and be used as a potential antitumor agent considering the expression of MUC4 in ovarian cancer patients.
In uninflamed CD ileum and IBD colon, most barrier gene levels restored to normal, except for MUC1 (show MUC1 Proteins) and MUC4 that remained persistently increased compared with controls. Genetic and transcriptomic dysregulations of key epithelial barrier genes and components in IBD. In particular MUC1 (show MUC1 Proteins) and MUC4, play an essential role in the pathogenesis of IBD and could represent interesting targets for treatment.
TNFalpha (show TNF Proteins) induced upregulation of MUC4 that reduced trastuzumab binding to its epitope and impaired ADCC. Silencing MUC4 enhanced trastuzumab binding, increased ADCC, and overcame trastuzumab and trastuzumab-emtansine antiproliferative effects in TNFalpha (show TNF Proteins)-overexpressing cells. In HER2 (show ERBB2 Proteins)-positive breast cancer samples, MUC4 expression was found to be an independent predictor of poor disease-free survival.
MUC4 is a novel and useful negative immunohistochemical marker for differentiating sarcomatoid mesothelioma from lung sarcomatoid carcinoma
NIDO, AMOP and vWD (show VWF Proteins) domains of MUC4 play synergic roles in MUC4 mediated signaling in pancreatic cancer cells.
MUC1 and MUC4 expression are increased by hypoxia and DNA hypomethylation; this status is statistically associated with development of distant metastasis, tumor stage and overall survival for pancreatic ductal adenocarcinoma (stage IIA and IIB) patients
Study provides evidence that AMOP domain plays the key role in MUC4-mediated tumor angiogenesis and metastasis of pancreatic cancer cells partly through the NOTCH3 signaling and its downstream target genes: VEGF-A, MMP-9 and ANG-2.
elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (show NR1H4 Proteins)/FAK (show PTK2 Proteins)/c-Jun (show JUN Proteins) axis to upregulate MUC4 expression.
High MUC4 expression is associated with CRLF2 (show CRLF2 Proteins)-rearranged acute lymphoblastic leukemia.
Polymorphism of FUT1 (show FUT1 Proteins) and MUC4 associated with resistance to colibacteriosis was determined.
Haplotype phylogeny analyses indicated that MUC4 had evolved divergently in Chinese and Western pigs.
A SNP in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify ETEC susceptible pigs.
data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
, mucin 4, ASGP
, pancreatic adenocarcinoma mucin
, testis mucin
, mucin 4, tracheobronchial
, tracheobronchial mucin
, pre-sialomucin complex
, sialomucin ascites sialoglycoprotein-1
, sialomucin complex