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Human Monoclonal SH2D1A Primary Antibody for ELISA, WB - ABIN561703
Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. in Immunology and cell biology 2009
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Human Polyclonal SH2D1A Primary Antibody for WB - ABIN1881802
Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. in The Journal of clinical investigation 2009
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Human Polyclonal SH2D1A Primary Antibody for IP, WB - ABIN4369745
Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. in Nature 1998
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Human Polyclonal SH2D1A Primary Antibody for ELISA, WB - ABIN250561
Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. in Blood 2004
Human Polyclonal SH2D1A Primary Antibody for ELISA, WB - ABIN251451
Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). in Tissue antigens 2004
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
, Signaling lymphocytic activation molecule-associated protein
, Duncan disease homolog