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Our finding suggested that TAP1-rs1135216, TAP1-rs4148873, TAP2-rs2228396, TAP2-rs241447 and TAP2-rs4148873 might not be involved in cancer risk, but the T allele of TAP2-rs4148876 might be a potential biomarker for judging cancer risk [review, meta-analysis]
In a meta-analyses of 6 studies with 415 cases and 659 controls, a significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and ankylosing spondylitis compared with combined control group.
Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor
PSMB8 (show PSMB8 Proteins) rs2071464 was associated with generalized and active vitiligo (show MITF Proteins) from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 (show PSMB8 Proteins) in patients with risk genotype 'CC' advocates the vital role of PSMB8 (show PSMB8 Proteins) in the autoimmune basis of vitiligo (show MITF Proteins).
Study compared the biochemical properties of the nucleotide-binding domains (NBD) of human and rat TAP1; suggests that although the D-helix sequence is not conserved in ABC (show ABCB6 Proteins) transporters, its precise positioning within the NBD structure has a critical role in NBD dimerization.
Significant associations between sorafenib exposure and the studied polymorphisms were observed for ABCB2
this study shows that TAP1 plays a novel role in the negative regulation of virus-triggered NF-kappaB (show NFKB1 Proteins) signaling and the innate immune response by targeting the TAK1 (show MAP3K7 Proteins) complex
there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients
The disruption of TAP1 and TAPBP (show TAPBP Proteins) generates pluripotent embryonic stem cells with reduced immunogenicity.
TAP1/2 gene polymorphisms might be associated with pulmonary tuberculosis susceptibility among patients in Zahedan, southeast Iran.
It transport class I antigens to cell surface of CD8 (show CD8A Proteins) positive lymphocytes which have a vital role in liver inflammation like fructose-induced steatosis.
Knocking out Tap1 abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
Apoe (show APOE Proteins)(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe (show APOE Proteins)(-/-) mice, indicating a minor role for CD8 (show CD8A Proteins)(+) T cells and TAP1-dependent antigen presentation in the disease process.
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (show HLADRB4 Proteins) (HLA)-B7 class I antigen presentation.
A complete overview is presented of the applicability of herpesvirus-encoded TAP and tapasin (show TAPBP Proteins) inhibitors in mouse cells of different genetic background.
Our results do not support a role for MHC class I (TAP1) in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.
a new role for mouse TAP2 in stabilizing TAP1 protein expression is shown using the Jasmine strain; Jasmine has an A to C transversion in exon 5 of TAP2, resulting in a threonine to proline substitution at position 293 of the protein.
Allergen-specific CD8 (show CD8A Proteins)+ T cells were recruited to and specifically activated in the lungs of sensitized animals after allergen-aerosol challenge, a process that was dependent on a functional TAP complex
MHC conformational changes, revealed at molecular level, may influence the immunogenicity
Macrophages cross-presented p33 (show LTB Proteins)-VLP (show VHLL Proteins) normally in the absence of TAP. The TAP-dependent pathway of cross-presentation is therefore confined to DC while both macrophages and DC harbor the TAP-independent pathway.
data indicate that TAP1 expression is increased by demethylation of promoter CpG islands, with CpG_4, CpG_13 and CpG_15 implicated as the critical regulatory sites
The TAP1 mRNA levels in GG genotype were significantly higher than that in the other two genotypes, with significant differences in the liver, lung, kidney, thymus, lymph node, duodenum and jejunum tissues.
These analyses showed that the TAP1 gene, which was related to MHC I immune regulation, had a stable and low expression level in unweaned stages; however, its expression increased in the postweaning stages.
The TAP1 gene is associated with swine immune responses.
Two splice variants of TAP1 were found.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
ABC transporter, MHC 1
, ATP-binding cassette sub-family B member 2
, ATP-binding cassette, sub-family B (MDR/TAP), member 2
, antigen peptide transporter 1
, peptide supply factor 1
, peptide transporter PSF1
, peptide transporter TAP1
, peptide transporter involved in antigen processing 1
, really interesting new gene 4 protein
, transporter associated with antigen processing
, transporter, ATP-binding cassette, major histocompatibility complex, 1
, transporter associated with antigen processing 1a
, transporter associated with antigen presentation 1
, transporter associated with antigen processing 1
, transporter 1 ATP-binding cassette sub-family B
, ABC transporter, MHC, 1
, ATP dependent transport protein family member
, ATP-binding cassette transporter, major histocompatibility complex, 1
, histocompatibility antigen modifier 1
, transporter 1, ABC (ATP binding cassette)
, transporter, ABC, MHC, 1
, transporter 1 ABC (ATP binding cassette)