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Human Polyclonal XCL1 Primary Antibody for ELISA, WB - ABIN562827
Venetz, Ponzoni, Schiraldi, Ferreri, Bertoni, Doglioni, Uguccioni: Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. in International journal of cancer. Journal international du cancer 2010
Human Polyclonal XCL1 Primary Antibody for Func, IHC (p) - ABIN2475402
Kennedy, Kelner, Kleyensteuber, Schall, Weiss, Yssel, Schneider, Cocks, Bacon, Zlotnik: Molecular cloning and functional characterization of human lymphotactin. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 2 Pubmed References
Human Polyclonal XCL1 Primary Antibody for ELISA - ABIN4219731
Tuinstra, Peterson, Kutlesa, Elgin, Kron, Volkman: Interconversion between two unrelated protein folds in the lymphotactin native state. in Proceedings of the National Academy of Sciences of the United States of America 2008
study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
The interaction between XCL1 and XCR1 (show XCR1 Antibodies) plays a crucial role in the classical immunology response.
Data show that mice lacking either XCL1 or XCR1 (show XCR1 Antibodies) exhibit similar specific defects in intestinal T cell populations as XCR1 (show XCR1 Antibodies)-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1 (show XCR1 Antibodies)-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1 (show XCR1 Antibodies)+ DCs or be independent of this pathway.
T inflammatory memory CD8 (show CD8A Antibodies) T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production
XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire (show AIRE Antibodies).
Data report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells.
The expression patterns of XCR1 (show XCR1 Antibodies) and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets.
MIP-1alpha (show CCL3 Antibodies), MIP-1beta (show CCL4 Antibodies), RANTES (show CCL5 Antibodies), and ATAC/lymphotactin function together with IFN-gamma (show IFNG Antibodies) as type 1 cytokines.
Adenovirus-mediated intratumoral Lptn gene transfer potentiates the antibody-targeted superantigen therapy of experimental melanoma.
In a brain-targeted HIV-1 Tat transgenic model, Tat exp (show TAT Antibodies)ression up-regulates XCL1 production not only in Tat-expressing murine astrocytes, but also in monocytes and macrophages/microglia.
higher serum XCL1 levels at diagnosis and their progressive decline throughout chemotherapy could be correlated with higher survival.
This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition.
Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin
XCL1 acts via direct interaction with the external viral envelope glycoprotein (show ERVW-1 Antibodies), gp120 (show ITIH4 Antibodies), to block HIV-1 infection
analysis of XCL1 and XCL2 (show XCL2 Antibodies), members of the C-chemokine (show CCL1 Antibodies) subfamily, in the immune system
identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3 (show CCL3 Antibodies), CCL4/CCL4L1 (show CCL4 Antibodies)/CCL4L2, CD160 (show CD160 Antibodies), IFNG (show IFNG Antibodies), NR4A3 (show NR4A3 Antibodies) and XCL1/XCL2 (show XCL2 Antibodies)) were analyzed in 127 kidney biopsies
XCL1 displays antimicrobial activity against E. coli and S. aureus.
XCL1-mediated inhibition is associated with direct interaction of the chemokine (show CCL1 Antibodies) with the HIV-1 envelope.
In native annulus fibrosus tissue homeostasis and repair, CXCR3 (show CXCR3 Antibodies) is evident, whereas XCL1 could not be detected.
The distribution characters of cattle XCR1 (show XCR1 Antibodies) and XCL1 suggested a vital role in regulation of acquired immune responses and indicated a potential for a DC targeted veterinary vaccine in cattle using XCL1 fused antigens.
This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
chemokine (C motif) ligand 1
, c motif chemokine 1
, cytokine SCM-1
, small inducible cytokine subfamily C, member 1 (lymphotactin)
, small-inducible cytokine C1
, XC chemokine ligand 1
, single cysteine motif 1a