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XCL1-XCR1 chemokine pathway promotes trophoblast invasion by increasing matrix metalloproteinase activity in human first-trimester placenta
higher serum XCL1 levels at diagnosis and their progressive decline throughout chemotherapy could be correlated with higher survival.
This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition.
Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin
XCL1 acts via direct interaction with the external viral envelope glycoprotein, gp120, to block HIV-1 infection
analysis of XCL1 and XCL2, members of the C-chemokine subfamily, in the immune system
identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies
XCL1 displays antimicrobial activity against E. coli and S. aureus.
XCL1-mediated inhibition is associated with direct interaction of the chemokine with the HIV-1 envelope.
In native annulus fibrosus tissue homeostasis and repair, CXCR3 is evident, whereas XCL1 could not be detected.
The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets.
Data indicated increased expression of XCL1 in CD4+ and CD8+ T cells in Wegener's granulomatosis (WG), and suggest that XCL1 might be a key modulator of T cell recruitment in WG.
NMR spectra of human lymphotactin (hLtn), obtained under various solution conditions, have revealed that the protein undergoes a major conformational rearrangement dependent on temperature and salt concentration.
lymphotactin, as well as MCP-1, may contribute to leukocyte infiltration and disease progression in IgA nephropathy.
Lymphotactin, (MIP)-1alpha, and MIP-1beta chemokines were all rapidly induced by engagement of CD28 and were calcineurin sensitive.
Lptn might be a key modulator for T cell trafficking in the pathogenesis of rheumatoid arthritis
In humans XCL1 expression is mainly a property of CD8+ T cells; the contribution to its synthesis by different T cell receptor alpha beta-expressing T cell subsets, namely CD4+ lymphocytes, is negligible.
lymphotactin utilizes highly specific glycosaminoglycan-binding sites
XCL1 activation is positively correlated with HIV-1 Tat expression in human U87.MG astrocytes in vitro.
description of a lymphotactin-producing monoclonal T-cell lymphoproliferative disorder with extreme lymphocytopenia and progressive leukoencephalopathy [case report]
A highly active form of XCL1 is a promising vaccine adjuvant for cross-presenting DCs to induce antigen-specific effector and memory CD8(+) T cells.
study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
The interaction between XCL1 and XCR1 plays a crucial role in the classical immunology response.
Data show that mice lacking either XCL1 or XCR1 exhibit similar specific defects in intestinal T cell populations as XCR1-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1+ DCs or be independent of this pathway.
T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production
XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire.
Data report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells.
MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines.
Adenovirus-mediated intratumoral Lptn gene transfer potentiates the antibody-targeted superantigen therapy of experimental melanoma.
In a brain-targeted HIV-1 Tat transgenic model, Tat expression up-regulates XCL1 production not only in Tat-expressing murine astrocytes, but also in monocytes and macrophages/microglia.
Lymphotactin gene-modified dendritoma induces T-cell proliferation and strong cytotoxic T lymphocytes reaction against allogenic hepatocellular carcinoma cells.
Results describe the role of XCL1 during the course of the immune response to pulmonary M. tuberculosis infection.
The distribution characters of cattle XCR1 and XCL1 suggested a vital role in regulation of acquired immune responses and indicated a potential for a DC targeted veterinary vaccine in cattle using XCL1 fused antigens.
This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
, XC chemokine ligand 1
, c motif chemokine 1
, cytokine SCM-1
, single cysteine motif 1a
, small inducible cytokine subfamily C, member 1 (lymphotactin)
, small-inducible cytokine C1
, chemokine (C motif) ligand 2
, X-C motif chemokine ligand 1
, chemokine XCL1/LYMPHOTACTIN