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Haplotype G-C-A of CYP4A11 was associated with increased risk of coronary artery disease.
The DEGs, such as AGTR1 (show AGTR1 Antibodies), CYP3A4 (show CYP3A4 Antibodies) and CYP4A11 may play critical roles in the development of HTN likely via the regulation by hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-26b-5p and taking part in some pathways.
Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
These results point to a potential 20-HETE dependence of intrarenal angiotensinogen (show AGT Antibodies) production and ANGII receptor type 1 activation that are associated with increases in NCC (show SLC12A3 Antibodies) and SGK1 (show SGK1 Antibodies) and identify elevated P450 (show CYP2B6 Antibodies) 4A11 activity and 20-HETE as potential risk factors for salt-sensitive human hypertension by perturbation of the renal renin (show REN Antibodies)-angiotensin axis.
CYP4A11 Variants are associated with Ischemic Stroke.
The results suggest that individuals carrying the alleles, K276T and S353G, might exhibit higher catalysis of CYP4A11
CYP4A1l rs9333025 GG and CYP4F2 (show CYP4F2 Antibodies) rs2108622 GG two-loci interaction significantly increases the risk for IS and an elevated 20-HETE level.
Single nucleotide polymorphism of CYP4A11 gene is associated with Plaque in Patients with Ischemic Stroke.
Interaction among CYP2C8 (show CYP2C8 Antibodies), EPHX2 (show EPHX2 Antibodies), and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke.
The present study focused on 10 CYP4A11 variant alleles and evaluated their functional characteristics using arachidonic acid as the substrate in a COS-7 cell-based expression system.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.
, 20-hydroxyeicosatetraenoic acid synthase
, alkane-1 monooxygenase
, cytochrome P-450HK-omega
, cytochrome P450 4A11
, cytochrome P450, subfamily IVA, polypeptide 11
, cytochrome P450HL-omega
, fatty acid omega-hydroxylase
, lauric acid omega-hydroxylase
, cytochrome P450 family 4 subfamily A
, cytochrome P450, family 4, subfamily A, polypeptide 11