No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Study showed that 5'isomiRNA of miR-140-3p (miR-140-3p-1) was preferentially expressed during the entire spectrum of preneoplastic progression in the MCF10A-derived triple negative breast cancer model. miR-140-3p-1 and its novel direct gene targets, HMGCR and HMGCS1, key enzymes in the cholesterol biosynthesis pathway, were deregulated in the normal-to-preneoplastic transition.
Data suggest that HMGCS1 (HMG-CoA synthase 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF(V600E)-dependent MEK1 activation in BRAF(V600E)-positive melanoma and colon cancer cells; HMGCS1 co-localizes with HMGCL (HMG-CoA lyase) and BRAF(V600E) in cytosol of melanoma and colon cancer cells. (BRAF = proto-oncogene protein B-raf)
The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway.
Mutation of hmgcs1 had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 mutants.
This study identified a mutation of hmgcs1, coding for Hmg-CoA synthase 1, which caused OPCs to migrate past their target axons and interfered with myelin gene expression.
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase
, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
, hydroxymethylglutaryl-CoA synthase, cytoplasmic
, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) isoform 1
, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) isoform 2
, 3-hydroxy-3-methylglutaryl coenzyme A synthase
, HMG-CoA synthase
, hydroxymethylglutaryl-CoA synthase 1
, hydroxymethylglutaryl coenzyme A synthase
, hydroxymethylglutaryl-CoA synthase, cytoplasmic-like