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Human Polyclonal NPAS2 Primary Antibody for IF, WB - ABIN518417
Plikus, Vollmers, de la Cruz, Chaix, Ramos, Panda, Chuong: Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. in Proceedings of the National Academy of Sciences of the United States of America 2013
NPAS2 hypomethylation occurs at the early stage of PD and is a moderate biomarker for distinguishing PD patients from healthy subjects.
NPAS2 has a critical role in HCC cell survival and tumor growth, which is mainly mediated by transcriptional upregulation of CDC25A.
Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (ppathway < 0.00625). The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (pgene = 0.00078); the latter being significant after Bonferroni correction.
Significantly, this study is the first to show that a variant copy number GGC repeat sequence in the NPAS2 clock gene associates with melanoma risk and which may be useful in the assessment of melanoma predisposition.
CLOCK, ARNTL, and NPAS2 gene polymorphisms may have a role in seasonal variations in mood and behavior
Genetic variations in NPAS2 might be a biomarker for a seasonal pattern in bipolar disorders.
With whole-exome sequencing a novel mutation in NPAS2 was identified in a Turkish family with nonobstructive azoospermia.
NPAS2 rs2305160 polymorphism does not appear to have any association with risk of chronic lymphocytic leukemia in our Pakistani population.
distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between schizophrenic patients with and without RLS
Two single nucleotide polymorphisms in RORA were associated with breast cancer in the whole sample and among postmenopausal women, and we also reported an association with CLOCK, RORA, and NPAS2 in the analyses at the gene level
Functional rs1053096 and rs2305160 polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients.
NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer.
Variants in NPAS2 have been associated with seasonality and seasonal affective disorder, phenotypes that could reflect circadian rhythm disruption.
Genetic variants of NPAS2 associate with seasonal affective disorder or winter depression.
Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS.
found a novel functional SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3'UTR of NPAS2
ARNTL and NPAS2 SNPs were associated with reproduction and with seasonal variation.
Data demonstrate that NPAS2 is also a RORalpha and REV-ERBalpha target gene.
A high level of NPAS2 expression was strongly associated with improved disease free survival & overall survival. The Ala/Ala, Ala/Thr, & Thr/Thr genotypes were also differentially distributed by tumor severity, as measured by TNM classification.
A significant difference between patients with seasonal affective disorder (SAD) and controls is found for NPAS2 protein (471 Leu/Ser) indicating a recessive effect of the leucine allele on SAD susceptibility.
Here we have provided an initial key insight into the interplay between neonatal establishment of the peripheral circadian clock in the liver and the ability of the gut microbiome to respond to dietary and metabolic stress.
In CLOCK-deficient fibroblasts, knockdown of Npas2 leads to arrhythmicity, suggesting that NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.
Study identified a unique role for Npas2 in the regulation of cocaine reward and dopamine Drd3 receptor expression
In the absence of NADPH, a change in pH from 6.5 to 8.0 decreased the KD(app) value of the E-box from 125 to 22 nM, with an 8-fold increase in the maximal level of DNA binding for the NPAS2/BMAL1 heterodimer.
Shp and Npas2 crosstalk is essential to maintain hepatic lipid homeostasis.
Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model.
BMAL1 in a complex with CLOCK or NPAS2 regulates cerebral redox homeostasis and connects impaired clock gene function to neurodegeneration.
Npas2 shows circadian expression in retinal ganglion cells in mice.And Contrast sensitivity is similarly reduced in Npas2-/- mice.
NPAS2 containing the N-terminal 61 residues forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like protein (BMAL1) to bind DNA; NAD(P)H enhances the binding activity.
DNA-binding of NPAS2 and BMAL1 to Per2 was also decreased by SD, although SD is known to increase Per2 expression in the cortex. DNA-binding to Per1 and Cry1 was not affected by SD
NPAS2 deletion produced significant impairment in the ability of the knockout mice to maintain body weight during restricted feeding and overnight food deprivation.
results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal light:dark cycle and feeding conditions and that NPAS2 is critical for adaptability to food restriction
CO binding disrupts the hydrogen bonding of His171 of NPAS2 with surrounding amino acids, which induces conformational changes in the His171-Cys170 moiety, leading to physiological signaling
overexpressed wild-type and His mutants of the PAS-B domain (residues 241-416) of mouse NPAS2 and then purified and characterized the isolated heme-bound proteins
the CLOCK(NPAS2)/BMAL1 complex is post-translationally regulated by cry1 and cry2
Results suggest that NPAS2 plays a role in sleep homeostasis, most likely at the level of the thalamus and cortex, where NPAS2 is abundantly expressed.
Brain protein domain binds specifically to the E-box DNA sequence in the presence, but not in the absence, of heme.
NPAS2 (MOP4) is able to functionally in the master brain clock in mice to regulate circadian rhythmicity.
Npas2 maintains rhythmic suprachiasmatic nucleus function in the absence of Clock, but Npas2 alone is unable to maintain rhythmicity in peripheral tissues.
These results indicate that the transcriptional activities of the mutants correlated well with their DNA-binding activities.
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.
neuronal PAS domain protein 2
, neuronal PAS domain-containing protein 2-like
, bHLH-PAS clock protein
, bHLH-PAS transcription factor MOP4
, member of PAS protein 4
, neuronal PAS domain-containing protein 2
, neuronal PAS2
, PAS domain-containing protein 4
, basic-helix-loop-helix-PAS protein MOP4
, class E basic helix-loop-helix protein 9
, member of PAS superfamily 4