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Mouse (Murine) NRF1 ELISA Kit for Sandwich ELISA - ABIN819118
Choi, Suh, Rhee, Kim: Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis. in Free radical research 2014
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Chronic kidney disease patients undergoing hemodialysis might be subjected to potential mitochondrial oxidative dysregulation and NRF1 (show NFE2L1 ELISA Kits) down-regulation.
Here the authors show that the aspartyl protease (show REN1 ELISA Kits) DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1 (show NFE2L1 ELISA Kits).
this study therefore identifies NRF-1 (show NFE2L1 ELISA Kits) as a novel regulator of HIF-1a (show HIF1A ELISA Kits).
our investigation shows that the ER membrane protein TCF11/Nrf1 (show NFE2L1 ELISA Kits) is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 (show NFE2L1 ELISA Kits) is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.
These results uncover a new regulatory mechanism that USP15 (show USP15 ELISA Kits) activates Nrf1 (show NFE2L1 ELISA Kits) against the beta-TrCP (show BTRC ELISA Kits) inhibition to maintain proteostasis.
NRF-1 (show NFE2L1 ELISA Kits) and its target mitochondrial transcription factor A (TFAM (show TFAM ELISA Kits)) were higher in Tamoxifen (TAM (show CCNA1 ELISA Kits))-resistant LCC2 and LCC9 cells than TAM (show CCNA1 ELISA Kits)-sensitive MCF-7 cells.
NRF1 (show NFE2L1 ELISA Kits) overexpression attenuated BPDEinduced Sphase arrest via the ATM (show ATM ELISA Kits)/Chk2 (show CHEK2 ELISA Kits) signaling pathway.
Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors
Low NRF1 (show NFE2L1 ELISA Kits) expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 (show EGLN2 ELISA Kits) associates with the NRF1 (show NFE2L1 ELISA Kits)-PGC1alpha complex and controls mitochondrial function in breast cancer
Study identifies the endoplasmic reticulum (ER)-bound transcription factor nuclear factor erythroid 2 related factor-1 (show NFE2L1 ELISA Kits), Nrf1/Nfe2L1 (show NFE2L1 ELISA Kits), as a critical mediator of this process and shows that Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain and that cholesterol regulates Nrf1 turnover, processing, localization, and activity.
data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis
Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65 (show NFkBP65 ELISA Kits)-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced (show SQSTM1 ELISA Kits) by As(III).
findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins
Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 (show HMOX1 ELISA Kits) expression
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation (show HELLS ELISA Kits), NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin (show INS ELISA Kits) secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin (show INS ELISA Kits)-secreting beta-cells.
lysine-specific demethylase (show MBD2 ELISA Kits) 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1.
Results show that Nrf1 may not be directly responsible for the loss of Nrf2 (show NFE2L2 ELISA Kits)-dependent inducibility of antioxidant and cytoprotective genes observed in aged animals.
Transcription Factor A (show GTF3A ELISA Kits) expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
, alpha palindromic-binding protein
, not really finished protein
, nuclear respiratory factor-1
, transcription factor
, nuclear respiratory factor 1