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Mice lacking PEX11-alpha have normal peroxisome abundance.
Cooperation with other transcription factors may be differentially involved in selective transactivation of the PEX11alpha gene by different peroxisome proliferator-activated receptor (show PPARD Proteins) subtypes.
Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions.
Pex11alpha deficiency impairs peroxisome elongation and abundance and peroxisomal fatty acid oxidation, which contributes to increased lipid accumulation in the liver.
required for peroxisome proliferation in response to 4-phenylbutyrate but dispensable for peroxisome proliferator-activated receptor alpha (show PPARA Proteins)-mediated peroxisome proliferation
PEX11a and peroxule formation play a key role in regulating stress perception and fast cell responses to environmental cues.
This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
peroxisomal biogenesis factor 11A
, 28 kDa peroxisomal integral membrane protein
, peroxisomal membrane protein 11A
, protein PEX11 homolog alpha
, peroxisomal biogenesis factor 11 alpha
, peroxisomal biogenesis factor 11a
, peroxisomal coatomer receptor
, peroxisomal membrane protein 26
, peroxisomal membrane protein Pmp26p (Peroxin-11)