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anti-Human PLIN2 Antibodies:
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Human Polyclonal PLIN2 Primary Antibody for ICC, IF - ABIN258339
Wohlers, Jackson, Spangenburg: Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. in Journal of cellular biochemistry 2011
Show all 12 Pubmed References
Human Polyclonal PLIN2 Primary Antibody for IHC, IHC (p) - ABIN258342
Goh, Tan, Tan, Seow, Ong, Lim, Sun, Ghosh, Silver: Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy. in The Journal of biological chemistry 2015
Show all 2 Pubmed References
Dog (Canine) Monoclonal PLIN2 Primary Antibody for IHC (fro), IF - ABIN112185
Heid, Schnölzer, Keenan: Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. in The Biochemical journal 1997
Show all 5 Pubmed References
Human Polyclonal PLIN2 Primary Antibody for WB - ABIN513123
Cantley, Yoshimura, Camporez, Zhang, Jornayvaz, Kumashiro, Guebre-Egziabher, Jurczak, Kahn, Guigni, Serr, Hankin, Murphy, Cline, Bhanot, Manchem, Brown, Samuel, Shulman: CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. in Proceedings of the National Academy of Sciences of the United States of America 2013
Human Polyclonal PLIN2 Primary Antibody for IHC (fro), IHC (p) - ABIN285650
Frances, Niemann: Stem cell dynamics in sebaceous gland morphogenesis in mouse skin. in Developmental biology 2012
Human Monoclonal PLIN2 Primary Antibody for ICC, FACS - ABIN1724917
Shepherd, Cocks, Tipton, Ranasinghe, Barker, Burniston, Wagenmakers, Shaw: Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise. in Experimental physiology 2012
Human Monoclonal PLIN2 Primary Antibody for ELISA, IF - ABIN5572070
Kern, Di Gregorio, Lu, Rassouli, Ranganathan: Perilipin expression in human adipose tissue is elevated with obesity. in The Journal of clinical endocrinology and metabolism 2004
PLIN2 protein levels are significantly increased in patients with neoatherosclerosis.
hese results suggested that PLIN2 may be considered a novel prognostic factor in Clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC) and a specific diagnostic indicator for patients with ccRCC. Furthermore, it could be a potential novel target for the clinical treatment of ccRCC
ADRP knockdown significantly inhibited PDGFinduced increases in Vascular smooth muscle cell viability, caused G1 phase cell cycle arrest and decreased PCNA (show PCNA Antibodies) expression.
this papet shows that adipophilin is a novel prognostic biomarker in clear cell renal cell carcinoma (show MOK Antibodies)
PLIN2 gene Ser251Pro missense mutation is associated with reduced insulin (show INS Antibodies) secretion and increased insulin (show INS Antibodies) sensitivity.
Interference with PLIN2 and PPARalpha (show PPARA Antibodies) resulted in major alterations in gene expression, especially affecting lipid, glucose, and purine metabolism.
This study shows that hepatitis C virus suppresses hepatic ADRP expression in infected patients and cell lines. Forcing the expression of miR (show MLXIP Antibodies)-148a and miR (show MLXIP Antibodies)-30a limits the suppressive effect of hepatitis C virus on ADRP.
ADP was expressed in a small proportion of lung adenocarcinoma suggesting that ADP-positive lung adenocarcinoma could be a distinct subtype of lung adenocarcinoma, induced by up-regulation of the lipogenic pathway.
Activation of ARF1 (show ARF1 Antibodies) dissociates ADRP from lipid droplets. A constitute active form of ARF1 (show ARF1 Antibodies) (ARF1Q71I) promotes HCV assembly. ADRP played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
PLIN2 expression is significantly upregulated in human masticatory mucosa during wound healing
Genetic ablation of Plin2 in Akita mice leads to mitigation of ER stress, forestalling beta cell apoptosis, partially restoring beta cell mass, and ameliorating diabetes.
Lipid-laden fibroblasts (lipofibroblasts) express the Perilipin 2 (Plin2) gene-product, PLIN2, commonly called adipose-differentiation related protein (ADRP)..The present study reports the generation of an inducible mouse Cre-driver line to target cells of the ADRP lineage. Robust Cre-mediated recombination in this mouse line was detected in mesenchymal cells of the postnatal lung
Plin2 is essential for protecting the pool of skeletal muscle lipid droplet
PLIN2 overexpression protects against autophagy, and its downregulation stimulates triglyceride catabolism via autophagy.
data shows that a host genotype can modulate microbiome function without impacting community structure and identify Plin2 as a specific host determinant of diet effects on microbial function.
Although lipopolysaccharide (LPS (show TLR4 Antibodies)) can trigger inflammation in atherosclerosis, how LPS (show TLR4 Antibodies) promotes atherogenesis through acting on macrophages is not very clear. Here, we study the role of adipophilin in LPS (show TLR4 Antibodies)-induced inflammation. LPS (show TLR4 Antibodies) can promote the expression of adipophilin through the ERK1/2-PPARgamma (show PPARG Antibodies) pathway.
Cardiac PLIN2 plays an important pathophysiological role in the development of dynamic steatosis and that the latter was prevented by upregulation of intracellular lipases, including Hormone-sensitive Lipase (show LIPE Antibodies).
Plin2 liver-specific ablation alleviates diet-induced hepatic steatosis and inflammation via a PEMT (show PEMT Antibodies)-mediated mechanism.
The relationship between M1-/M2-macrophage polarization and Adp-rich hepatocyte-consisting pseudolobules (PLs (show CTSC Antibodies)) was investigated in thioacetamide (TAA)-induced rat cirrhosis.
These results demonstrate that bovine embryos at the blastocyst stage expressed ADRP mRNA and protein, and that the embryonic culture system modified this expression.
Adipophilin and TIP47 (show PLIN3 Antibodies) are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.
25 novel polymorphisms were identified within all exons and their flanking regions of ADFP, including the promoter region.
PLIN1 (show PLIN1 Antibodies) and PLIN2 have been evaluated as candidate genes for growth, carcass and meat quality traits in pigs; two single-nucleotide polymorphisms, one in intron 2 of the PLIN1 (show PLIN1 Antibodies) gene (JN860199:g.173G>A) and the 3' untranslated region of the PLIN2 gene (GU461317:g.98G>A); results obtained indicate that the PLIN2 polymorphism could be a useful marker for lean growth.
These findings suggested that PLIN2 was a major lipid droplet-associated protein (show PLIN1 Antibodies) in porcine oocytes.
In pig muscle PLIN1 (show PLIN1 Antibodies) and PLIN2 proteins are localized in correspondence with extra and intra-myocellular lipids, respectively.
PLIN2 can be a marker for carcass quality in pigs.
an association between 7 SNPs and 6 possible ADFP combined haplotypes with production traits in goats was established in this study
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.
, adipose differentiation-related protein
, adipose differentiation related protein
, perilipin 2
, adipocyte differentiation-related protein