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Human Polyclonal HDAC5 Primary Antibody for IHC, WB - ABIN362218
Lim, Luo, Koh, Yang, bin Abdul Kadir, Tan, Ye, Wang, Melamed et al.: Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by ... in Molecular and cellular biology 2007
Show all 6 Pubmed References
Human Polyclonal HDAC5 Primary Antibody for ChIP, WB - ABIN2668266
Basile, Mantovani, Imbriano: DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. in The Journal of biological chemistry 2006
Show all 5 Pubmed References
Human Polyclonal HDAC5 Primary Antibody for IHC, WB - ABIN362746
Döppler, Storz, Li, Comb, Toker: A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. in The Journal of biological chemistry 2005
Show all 5 Pubmed References
Human Polyclonal HDAC5 Primary Antibody for IP, IHC - ABIN223300
Yamaguchi, Chakraborty, Pasek, Molkentin, Meissner: Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. in American journal of physiology. Heart and circulatory physiology 2011
Show all 2 Pubmed References
Human Polyclonal HDAC5 Primary Antibody for IHC - ABIN966266
McKinsey, Zhang, Lu, Olson: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. in Nature 2000
Show all 2 Pubmed References
Human Polyclonal HDAC5 Primary Antibody for ChIP, IP - ABIN4316754
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
Human Polyclonal HDAC5 Primary Antibody for ICC, IF - ABIN4316758
Baek, Park, Rhim, Park, Kim, Kim, Nam: Immunohistochemical Characterization of Histone Deacetylase as a Potential Prognostic Marker and Therapeutic Target in Endometrial Stromal Sarcoma. in Anticancer research 2016
High HDAC5 expression is associated with invasion of lung cancer.
HO-1 (show HMOX1 Antibodies) plays a key role in protecting tumor cells from apoptosis, in a process that involves Smad7 (show SMAD7 Antibodies) and HDAC4 (show HDAC4 Antibodies)/5 in apoptosis of B-ALL cells
Hdac5 and Hdac6 (show HDAC6 Antibodies) expression are required for the adequate expression of Icer (show CREM Antibodies) and adipocyte function. Altered adipose expression of the two Hdacs in obesity by hypoxia may contribute to the development of metabolic abnormalities.
These findings demonstrate a novel mechanism for deregulation of HDAC5 in non-small cell lung cancer (NSCLC)and suggest that miR5895p/HDAC5 pathway may represent a new prognostic biomarker and therapeutic target against NSCLC.
HDAC5 was extensively expressed in human BC tissues, and high HDAC5 expression was associated with an inferior prognosis.
HDAC5 is a negative predictor of disease-free and overall survival in pancreatic neuroendocrine tumor patients.
Interference with both glucose and glutamine (show GFPT1 Antibodies) supply in HDAC5-inhibited cancer cells significantly increases apoptotic cell death.
these results suggest that HDAC5 is critical in regulating LSD1 (show KDM1A Antibodies) protein stability through post-translational modification, and the HDAC5-LSD1 (show KDM1A Antibodies) axis has an important role in promoting breast cancer development and progression.
The expression of HDAC5 was significantly increased in endothelial cells (ECs) from patients with systemic sclerosis (SSc (show CYP11A1 Antibodies)) compared to healthy control endothelial cells. Silencing of HDAC5 in SSc (show CYP11A1 Antibodies) ECs restored normal angiogenesis. HDAC5 knockdown followed by ATAC (show XCL1 Antibodies)-seq assay in SSc (show CYP11A1 Antibodies) ECs identified key HDAC5-regulated genes involved in angiogenesis and fibrosis, such as CYR61 (show CYR61 Antibodies), PVRL2 (show PVRL2 Antibodies), and FSTL1 (show FSTL1 Antibodies).
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 (show HIPK2 Antibodies) in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5-homeodomain-interacting protein kinase-2 (show HIPK2 Antibodies)-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
class IIa HDAC (show HDAC3 Antibodies) function could be used to enhance metabolic health in chronic diseases driven by physical inactivity.
HDAC5 emerges as a cellular conductor of MEF2C (show MEF2C Antibodies) and M6a (show GPM6A Antibodies) activity and is regulated by miR (show MLXIP Antibodies)-124 and miR (show MLXIP Antibodies)-9 to control neurite development.
This paper presents data for the first time directly supporting the role of HDAC5 as a scaffold recruiting a chromatin modifying co-repressor complex to specific transcription factors on unique gene promoters. These data for HDAC5 may reflect one of the functions of class IIa HDACs in transcriptional regulation distinct from its catalytic activity.
This study demonstrated that decreased HDAC5 function is able to exacerbate the long-term behavioral effects of adverse rearing environment in mice
As HDAC5 expression may help nullify AIS (show AR Antibodies) and identify progenitor cells, the precise delivery of miD2861 may serve as a vehicle for monitoring network remodeling with target specificity and signal sensitivity after drug exposure that identifies brain repair processes in adult animals.
HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.
This study demonstrated that mice with learned helplessness protocol-induced behavioral despair exhibited higher levels of HDAC5 and HDAC5 binding to the promoter region of BDNF (show BDNF Antibodies) exon IV resulting in the decreased expression of BDNF (show BDNF Antibodies).
inhibition of HDAC5 differentially regulates ghrelin (show GHRL Antibodies) and NUCB2/ nesfatin-1 (show NUCB2 Antibodies) expression by enhancing the acetylation and phosphorylation of Raptor (show RPTOR Antibodies), which subsequently suppress mTORC1 signaling
Results suggest a role for Hdac5 and Sirt2 (show SIRT2 Antibodies) in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression
Protein kinase D (show PRKD1 Antibodies)-HDAC5 pathway plays an important role in VEGF (show VEGFA Antibodies) regulation of gene transcription and angiogenesis
Regulation of flowering time by the histone deacetylase HDA5
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Antibodies)-histone deacetylase 5-Kruppel-like factor signaling.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
, histone deacetylase 4
, histone deacetylase mHDA1
, histone deacetylase 5