Browse our anti-Histone Deacetylase 5 (HDAC5) Antibodies

Human Histone Deacetylase 5 (HDAC5) interaction partners

1. High HDAC5 expression is associated with invasion of lung cancer.

2. HO-1 (show HMOX1 Antibodies) plays a key role in protecting tumor cells from apoptosis, in a process that involves Smad7 (show SMAD7 Antibodies) and HDAC4 (show HDAC4 Antibodies)/5 in apoptosis of B-ALL cells

3. Hdac5 and Hdac6 (show HDAC6 Antibodies) expression are required for the adequate expression of Icer (show CREM Antibodies) and adipocyte function. Altered adipose expression of the two Hdacs in obesity by hypoxia may contribute to the development of metabolic abnormalities.

4. These findings demonstrate a novel mechanism for deregulation of HDAC5 in non-small cell lung cancer (NSCLC)and suggest that miR5895p/HDAC5 pathway may represent a new prognostic biomarker and therapeutic target against NSCLC.

5. HDAC5 was extensively expressed in human BC tissues, and high HDAC5 expression was associated with an inferior prognosis.

6. HDAC5 is a negative predictor of disease-free and overall survival in pancreatic neuroendocrine tumor patients.

7. Interference with both glucose and glutamine (show GFPT1 Antibodies) supply in HDAC5-inhibited cancer cells significantly increases apoptotic cell death.

8. these results suggest that HDAC5 is critical in regulating LSD1 (show KDM1A Antibodies) protein stability through post-translational modification, and the HDAC5-LSD1 (show KDM1A Antibodies) axis has an important role in promoting breast cancer development and progression.

9. The expression of HDAC5 was significantly increased in endothelial cells (ECs) from patients with systemic sclerosis (SSc (show CYP11A1 Antibodies)) compared to healthy control endothelial cells. Silencing of HDAC5 in SSc (show CYP11A1 Antibodies) ECs restored normal angiogenesis. HDAC5 knockdown followed by ATAC (show XCL1 Antibodies)-seq assay in SSc (show CYP11A1 Antibodies) ECs identified key HDAC5-regulated genes involved in angiogenesis and fibrosis, such as CYR61 (show CYR61 Antibodies), PVRL2 (show PVRL2 Antibodies), and FSTL1 (show FSTL1 Antibodies).

10. the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 (show HIPK2 Antibodies) in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5-homeodomain-interacting protein kinase-2 (show HIPK2 Antibodies)-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.

Mouse (Murine) Histone Deacetylase 5 (HDAC5) interaction partners

1. Hdac5 and Hdac6 (show HDAC6 Antibodies) expression are required for the adequate expression of Icer (show CREM Antibodies) and adipocyte function. Altered adipose expression of the two Hdacs in obesity by hypoxia may contribute to the development of metabolic abnormalities.

2. class IIa HDAC (show HDAC3 Antibodies) function could be used to enhance metabolic health in chronic diseases driven by physical inactivity.

3. HDAC5 emerges as a cellular conductor of MEF2C (show MEF2C Antibodies) and M6a (show GPM6A Antibodies) activity and is regulated by miR (show MLXIP Antibodies)-124 and miR (show MLXIP Antibodies)-9 to control neurite development.

4. This paper presents data for the first time directly supporting the role of HDAC5 as a scaffold recruiting a chromatin modifying co-repressor complex to specific transcription factors on unique gene promoters. These data for HDAC5 may reflect one of the functions of class IIa HDACs in transcriptional regulation distinct from its catalytic activity.

5. This study demonstrated that decreased HDAC5 function is able to exacerbate the long-term behavioral effects of adverse rearing environment in mice

6. As HDAC5 expression may help nullify AIS (show AR Antibodies) and identify progenitor cells, the precise delivery of miD2861 may serve as a vehicle for monitoring network remodeling with target specificity and signal sensitivity after drug exposure that identifies brain repair processes in adult animals.

7. HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.

8. This study demonstrated that mice with learned helplessness protocol-induced behavioral despair exhibited higher levels of HDAC5 and HDAC5 binding to the promoter region of BDNF (show BDNF Antibodies) exon IV resulting in the decreased expression of BDNF (show BDNF Antibodies).

9. inhibition of HDAC5 differentially regulates ghrelin (show GHRL Antibodies) and NUCB2/ nesfatin-1 (show NUCB2 Antibodies) expression by enhancing the acetylation and phosphorylation of Raptor (show RPTOR Antibodies), which subsequently suppress mTORC1 signaling

10. Results suggest a role for Hdac5 and Sirt2 (show SIRT2 Antibodies) in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

Cow (Bovine) Histone Deacetylase 5 (HDAC5) interaction partners

1. Protein kinase D (show PRKD1 Antibodies)-HDAC5 pathway plays an important role in VEGF (show VEGFA Antibodies) regulation of gene transcription and angiogenesis

Arabidopsis thaliana Histone Deacetylase 5 (HDAC5) interaction partners

1. Regulation of flowering time by the histone deacetylase HDA5

Zebrafish Histone Deacetylase 5 (HDAC5) interaction partners

1. Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Antibodies)-histone deacetylase 5-Kruppel-like factor signaling.