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Irxl1/Mkx can repress myoD (show MYOD1 Proteins) expression through direct binding to its promoter and may thus play a negative regulatory role in muscle differentiation.
observations suggest that irxl1 may regulate factors involved in brain and pharyngeal arch development
Data show that homeobox protein Mohawk (Mkx) is mainly expressed in the outer annulus fibrosus (OAF) of humans and mice.
these data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta (show TGFB1 Proteins) pathway.
Reduced expression of MKX is a feature of degenerated anterior cruciate ligament in osteoarthritis-affected joints.
In silico characterization of the C10orf48 sequence
Mkx prevents periodontal ligament degeneration by regulating osteogenesis.
Gtf2ird1 is essential for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration.
Mkx is an important regulator of the differentiation of VPs and pulleys, as well as of tendon differentiation.
Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.
these data identify the unique DNA-recognition properties of MKX and reveal a novel role for Mkx in promoting slow fiber type specification during skeletal muscle differentiation.
These results suggest that Irxl1 is required for the tendon differentiation but dispensable for the patterning of the musculoskeletal system in development.
Mkx mRNA was strongly expressed in differentiating tendon cells during embryogenesis and in the tendon sheath cells in postnatal stages. In addition to defects in tendon collagen fibrillogenesis, Mkx(-/-) mice exhibited abnormal tendon sheaths.
observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons.
The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.
, homeobox protein Mohawk
, homeobox protein mohawk A
, iroquois homeobox-like protein 1b
, homeobox protein Mohawk-like
, Iroquois family related homeodomain protein
, iroquois homeobox protein-like 1