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embryonic stem cell switching into the differentiation state can be initiated by a tissue-specific splicing regulator (show PTBP2 Antibodies), Rbm24.
Our results show that tissue-specific expression of RBM24 can explain the neuron-specific aberrant splicing of IKBKAP (show IKBKAP Antibodies) exon 20 in familial dysautonomia, and that ectopic expression of RBM24 in neuronal tissue could be a novel therapeutic target of the disease.
RBM24 acts at least in part through upregulating the expression of miR-25, which in turn targets MALAT1 for degradation.
Authors have identified a new function of microRNA-222 leading to alteration of myogenic differentiation at the level of alternative splicing, and provided evidence that this effect is mediated by Rbm24 protein.
Study suggests that p63 (show RPE65 Antibodies) is regulated by RBM24 via mRNA stability, which gives an insight into understanding how posttranscriptional regulatory mechanisms contribute to p63 (show RPE65 Antibodies) expression.
Rbm24 is a novel player in the p53 (show TP53 Antibodies) pathway, which may be explored to restore proper cell cycle control in p53 (show TP53 Antibodies)-deficient tumors via p21 (show CDKN1A Antibodies).
it was found that this protein Rbm24 regulates myogenic differentiation via the p21 (show CDKN1A Antibodies) signal pathway.
Study suggests that p63 (show CKAP4 Antibodies) is regulated by RBM24 via mRNA stability, which gives an insight into understanding how posttranscriptional regulatory mechanisms contribute to p63 (show CKAP4 Antibodies) expression.
RBM24 is sufficient to mediate muscle-specific (show EIF3K Antibodies) exon inclusion.
Rbm24 plays a crucial role in myogenic differentiation at least in part through a myogenin (show MYOG Antibodies)-dependent post-transcriptional regulatory pathway.
Seb4 (show RBM24-B Antibodies) is a target of MyoD (show MYOD1 Antibodies) during myogenesis and is required for myogenic gene expression.
Both Rbm24a and Rbm24b are also required for normal somite and craniofacial development.
Rbm24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility.
rbm24a is a key developmental cardiac genes with unequal roles in cardiovascular formation
Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and regulates its stability (By similarity).
RNA-binding protein 24
, RNA-binding motif protein 24
, RNA-binding region (RNP1, RRM) containing 1
, RNA binding motif protein 24
, RNA-binding region (RNP1, RRM) containing 6
, RNA-binding region-containing protein 6
, RNA-binding motif protein 24-A
, RNA-binding protein 24-A
, RRM domain-containing protein SEB-4
, RRM-containing protein SEB-4
, RNA binding protein
, RNA-binding protein SEB-4