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S100A2 (show S100A2 Proteins) and S100P can be used as specific duct markers in eccrine sweat glands, and combined use of S100P or S100A2 (show S100A2 Proteins) with keratins enables easy to distinction between secretory coils and ducts.
Data show that inhibition of S100 calcium binding protein P (S100P) results in reversing trastuzumab resistance (TzR) in proto-oncogene (show RAB1A Proteins) protein HER-2 (HER2 (show ERBB2 Proteins))-driven breast cancers.
the S100P protein may contribute to the outgrowth of aggressive tumor cells resistant to cytotoxic therapy and promote cancer progression.
Results found high plasma levels of S100P protein in patients with metastatic breast cancer which suggest its implication in disease progression.
activation of tissue plasminogen activator (show PLAT Proteins) via the C-terminal lysine of S100P contributes to the enhancement of cell invasion by S100P and thus potentially to its metastasis-promoting activity.
This study reveals significant association between blood-based decreased S100P methylation and Breast cancer (BC), and provides another proof for the application of altered DNA methylation (show HELLS Proteins) signatures from blood cells as potential markers for the detection of BC, especially for the early stage.
Novel positive feedback loop between Trx-1 (show MLL Proteins) and S100P promotes colorectal cancer invasion and metastasis.
An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma.
We established a novel quantitative analysis for the S100P protein in EUS-FNA samples which, when combined with EUS-FNA cytology, could provide promising results for the reliable diagnosis of pancreatic adenocarcinoma (PCA (show FLVCR1 Proteins))
S100P achieved 96.4% sensitivity, 93.3% specificity, 98.2% PPV (show PPP6C Proteins), 87.5% NPV and 95.8% total accuracy, while IMP3 (show IGF2BP3 Proteins) achieved 91.2% sensitivity, 86.7% specificity, 96.2% PPV (show PPP6C Proteins), 72.2% NPV and 90.3% total accuracy for pancreatic ductal adenocarcinoma (PDA).Both markers were sensitive and specific for diagnosis of PDA.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21\; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.
S100 calcium binding protein P
, S-100 protein beta chain
, S-100 protein subunit beta
, S100 calcium-binding protein B
, S100 calcium-binding protein beta (neural)
, S100 calcium-binding protein, beta (neural)
, S100 protein, beta polypeptide, neural
, protein S100-B
, S100 calcium-binding protein P
, migration-inducing gene 9 protein
, protein S100-E
, protein S100-P