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Horse (Equine) Arginine Vasopressin Receptor 1A (AVPR1A) interaction partners

1. Expression of oxytocin and vasopressin receptors in the equine conceptus between Days 10 and 16 of pregnancy.

Human Arginine Vasopressin Receptor 1A (AVPR1A) interaction partners

1. Study finds evidence of differential allele expression, in at least a third of human brain samples heterozygous for a reporter single nucleotide polymorphism (SNP) in the arginine vasopressin receptor 1a (AVPR1a) transcript. We also show that this functional effect and a downstream phenotype, externalizing behavior, are predicted by AVPR1a short tandem repeats but not SNPs.

2. Despite having a similar minor allele frequency (MAF) of 14.5% compared with the SMILE cohort, our results did not support an association of the mirSNP rs11174811 with the hypertension phenotype or with continuous blood pressure outcomes in the south Indian population.

3. The data of this study indicated that alterations in amygdala signalling may constitute a neural mechanism by which polymorphisms of the AVPR1A gene could influence ASD susceptibility.

4. These results demonstrate that polymorphisms in the AVPR1A promoter region might be involved in pathophysiology of ASD and in functional regulation of the expression of AVPR1A.

5. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues.

6. Three OXTR polymorphisms (rs2270465, rs2268493, rs7632287) and 2 AVPR1A polymorphisms (rs1587097, rs1042615) showed nominal effects (p < .05) on vocal symptoms, of which 1 (rs1587097) remained significant after correcting for multiple testing (p = .003). Study found potential mediation of the effect of the OXTR rs2268493 polymorphism on vocal symptoms through levels of cortisol.

7. Using a mixed mediation and moderation model, study found that the gray matter volume of the right fusiform face area mediated the association between AVPR1A RS3 and altruistic behavior. Moreover, this mediation effect was significant only in male subjects.

8. Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and acute-on-chronic liver failure.

9. The gene-based analysis indicated association of variation within AVPR1A with aggressive behavior. We conclude that common variants at 2p12 show suggestive evidence for association with childhood aggression.

10. Association between neural activation of the anterior prefrontal cortex in mothers and fathers in response to their child smiling video stimuli to induce the positive affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A).

11. Study used brainstem tissue containing this region in order to validate a reliable, pharmacologically informed receptor autoradiography protocol for use in human brain tissue more broadly and to establish where OXTR and AVPR1a are expressed in adjacent regions in the human brainstem.

12. Mothers with long alleles for AVPR1a and DRD4 engaged in more mother-oriented social cognition, which in turn predicted less sensitive maternal behavior. There were no significant direct effects of AVPR1a or DRD4 on maternal sensitivity (beta = 0.02, P = .73 and beta = -0.10, P = .57, respectively).

13. The arginine vasopressin receptor 1A gene (AVPR1A) is known to affect social communication and has been reported to associate with autism in several studies.

14. Higher acute vulnerability to stress exists in persons with long AVPR1A RS3 alleles and increased arginine vasopressin levels.

15. examined associations between polymorphisms in OXTR and AVPR1a and individual differences in emotional and cognitive empathy 367 young adults; emotional empathy was associated solely with OXTR, whereas cognitive empathy was associated solely with AVPR1a

16. AVPR1A RS3 was not associated with schizophrenia; variation in the AVPR1A gene contributes to social behavioral deficits associated with schizophrenia

17. Study identified, in OXTR and AVPR1A genes, signatures of balancing selection in the cis-regulative acting sequences such as transcription factor binding and enhancer sequences, as well as in a transcriptional repressor sequence motif. Additionally, in the intron 3 of the OXTR gene, the SNP rs59190448 appears to be under positive directional selection.

18. Haplotype analysis revealed an association of AVPR1A C*S- and C*L-haplotype (rs11174811 and RS1, respectively) and increased or decreased Extraversion (EPI) in Bashkirs, respectively.

19. Study found that variability in the rs7298346 marker, located in the 5'-flanking region, was related to a composite measure of executive functioning in 4-year-old children after controlling for a variety of covariates and children's theory of mind.

20. Gene-level tests showed that DRD2 was associated with vocabulary, ASPM with vocabulary and reading decoding, and AVPR1A with all three endophenotypes.

Mouse (Murine) Arginine Vasopressin Receptor 1A (AVPR1A) interaction partners

1. depressive-like behavior alters oxytocin receptor (OxtR) and arginine vasopressin receptor type 1a (AvpR1a) gene expression in the hippocampus (HC) of male mice.

2. Data indicate the upregulation of vasopressin receptor 1 (V1R) expression on hepatocytes upon liver ischemia-reperfusion injury (IRI).

3. Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function.

4. The results suggest that vasopressin receptor is required for conditioned effects of an ethanol-associated social stimulus

5. Local over-expression of the AVP receptor V1a enhances regeneration of atrophic muscle.

6. Oxytocin inhibits ASICs through V1A receptors in sensory neurons modulating nociception and pain.

7. Transaortic constriction decreased heart function and betaAR density. It increased V1AR expression. V1AR decreased cardiomyocyte betaAR ligand affinity, betaAR-induced calcium signaling and cAMP in a Gq protein-independent/G protein receptor kinase-dependent way.

8. Using homologous recombination in mice, we reveal the modest contribution of proximal 5' flanking sequences to species differences in V1aR distribution, and confirm that variation in V1aR distribution impacts stress-coping in the forced swim test.

9. Central V1a receptors might play an important role in suppressing baroreflex control of heart rate during cerebral activation at the onset of voluntary locomotion.

10. V1aR signaling may be fundamentally important for the expression of AQP2 in the collecting ducts during control conditions and dehydration

11. this study found that circadian rhythms of behavior (locomotor activity), clock gene expression, and body temperature immediately reentrained to phase-shifted light-dark cycles in mice lacking vasopressin receptors V1a and V1b (V1a(-/-)V1b(-/-)).

12. Females, but not males, show an orienting bias for odors previously paired with the mother, which is eliminated by V1aR signaling.

13. individual differences in developmentally transient V1aR signaling and even sex may alter the development of excitation and inhibition balance in the neocortex

14. These results suggest that vasopressin directly regulates the nucleocytoplasmic transport of mineralocorticoid receptors via the V1aR in the intercalated cells of the collecting ducts.

15. we do find evidence for the role of V1a receptors in predicting maternal behavior in mice

16. Total elimination of Avpr1a had no effect on fear conditioning in mice

17. Results suggest that variations of estrogen alpha/beta receptor levels are associated with differences in social interaction through the OT and AVP systems, by upregulating gene expression for those peptides and the oxytocin and vasopressin 1a receptors.

18. The V1a receptor (V1aR) for vasopressin, a potent myogenic-promoting factor that stimulates differentiation and hypertrophy in vitro, is expressed in mouse skeletal muscle and modulated during regeneration after experimental injury.

19. Aldosterone requires vasopressin V1a receptors on intercalated cells to mediate acid-base homeostasis.

20. Suggest that the V1aR is involved in the elevation of arterial blood pressure caused by dietary salt and that a V1aR antagonist could have significant therapeutic potential in the treatment of hypertension.