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These results suggest a novel function of corin in Mesenchymal stem cells differentiation and chondrocyte development.
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Enhanced serum corin level in humans and rodents is positively correlated with high salt diet-induced systolic blood pressure and 24-hour urinary Na+ and albumin excretion, which suggests that corin is involved in the salt-water balance in response to HS intake.
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corin may play important roles in aorta physiology and in the pathophysiological process of atherosclerosis in an autocrine manner
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Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 to activate corin; soluble corin and PCSK6 are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 = proprotein convertase subtilisin/kexin type-6)
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Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia.
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These results indicate that genetic variants impairing corin function are not uncommon in general populations and that such variants may be an important contributing factor in hypertension.
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Preeclampsia is one of the most severe complications of the pregnancy, and trials to estimate a panel of predictive markers are of big interest for multiple researches. Corin is a transmembrane serine protease, localized in the heart, which is converting pro-ANP in to active ANR. ANP is a hormone regulating salt hemostasis and arterial blood pressure. [review]
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Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease.
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association of 2 single nucleotide polymorphisms in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China
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We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension.
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Corin and atrial natriuretic peptide A were most abundant in the proximal convoluted tubules and the medullary connecting ducts.
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CORIN expression is significantly downregulated in human masticatory mucosa during wound healing
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serum levels of corin are significantly decreased in acute myocardial infarction patients
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Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
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Circulating corin concentrations are related to infarct size in patients after ST-segment elevation myocardial infarction
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Hypertensive participants had an increased serum corin level compared to those without hypertension, suggesting that corin may play a role in the pathology of hypertension.
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Serum soluble corin was significantly and positively associated with dyslipidemia
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Plasma corin levels decreased significantly from preoperative concentrations after coronary artery bypass graft surgery.
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corin may play an important role in the pathology of atrial fibrillation
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Increased serum soluble corin in mid pregnancy was associated with an increased risk for HDP(hypertensive disorders of pregnancy) .--increased serum soluble corin in mid pregnancy could be an indicator for HDP