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overexpression of XPO5 causes dysregulation in the miRNA processing mechanism, resulting in a shift in protein stability via lower ubiquitination and hyper N-linked glycosylation, as well as conferring a growth advantage by suppressing the DNA damage response.
data strongly strengthened the notion that phosphorylation of XPO5 by ERK (show EPHB2 Proteins) downregulates miRNA expression in clinical samples and is correlated with poor clinical outcomes of HCC (show FAM126A Proteins) patients
Aberrant XPO5 expression is important for the maturation of miRNAs and the malignant behavior of melanoma cells. High abundance of XPO5 in melanoma leads to enhanced survival, proliferation and metastasis.
XPO5 acts like an oncogene (show RAB1A Proteins) in colorectal cancer by regulating the expression of miRNAs and may be a potential therapeutic target in colorectal cancer
one SNP in XPO5 extron (rs2257082) was significantly associated with lead-poisoning; there were no significant association between the other six SNPs and the blood lead levels; polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations
SNP rs11077 influences the expression of XPO5, and this SNP could also be a potential biomarker for the diagnosis of thyroid cancer, especially in Chinese population
findings suggest that XPO5 functions as a potential tumor suppressor in the development and progression of HCC (show FAM126A Proteins) as well as a promising molecular target for HCC (show FAM126A Proteins) therapy
The microRNA-related single-nucleotide polymorphisms rs11077 of XPO5 may be independently connected with the prognosis and chemotherapy response of advanced non-small-cell lung cancer patients
XPO5 role in microRNA biogenesis
NUP93 (show NUP93 Proteins) and exportin 5 interact with the signaling protein SMAD4 (show SMAD4 Proteins) and that NUP93 (show NUP93 Proteins) mutations abrogated interaction with SMAD4 (show SMAD4 Proteins)
Exp5 exports eEF1A (show EEF1A1 Proteins) via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
miRNA biogenesis components Drosha (show DROSHA Proteins), Dgcr8 (show DGCR8 Proteins), Exportin-5 and Dicer1 (show DICER1 Proteins) are expressed in the mouse uterus and that Exportin-5 and Dicer1 (show DICER1 Proteins) appear to be the major steroid regulated components in the miRNA biogenesis pathway
Exp5 exports eEF1A (show EEF1A2 Proteins) via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.
, ran-binding protein 21
, exportin 5
, KIAA1291 protein-like