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Browse our anti-HMGCS2 (HMGCS2) Antibodies

Full name:: anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) Antibodies (HMGCS2)

On www.antibodies-online.com are 46 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Antibodies from 14 different suppliers available. Additionally we are shipping HMGCS2 Kits (20) and HMGCS2 Proteins (11) and many more products for this protein. A total of 84 HMGCS2 products are currently listed.

Synonyms:: 1300002P16, DDBDRAFT_0219349, DDBDRAFT_0219924, DDB_0219349, DDB_0219924, hmgCoA, Hmgcs1, mHS, Mt3h3mg

list all antibodies	Gene Name	GeneID	UniProt
	HMGCS2	3158	P54868
	HMGCS2	15360	P54869
	HMGCS2	24450
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Most Popular Reactivities for anti-HMGCS2 (HMGCS2) Antibodies

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anti-Human HMGCS2 Antibodies:

35 WB Antibodies

anti-Mouse (Murine) HMGCS2 Antibodies:

15 WB Antibodies

anti-Rat (Rattus) HMGCS2 Antibodies:

14 WB Antibodies

All available anti-HMGCS2 Antibodies

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Relevant Pathways for anti-HMGCS2 Antibodies

Regulation of Lipid Metabolism by PPARalpha

More product categories related to HMGCS2 Antibody

Top referenced anti-HMGCS2 Antibodies

Cow (Bovine) Polyclonal HMGCS2 Primary Antibody for WB - ABIN2776880 : Bouchard, Robert, Vinarov, Stanley, Thompson, Morris, Leonard, Quant, Hsu, Boneh, Boukaftane, Ashmarina, Wang, Miziorko, Mitchell: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients. in Pediatric research 2001 (PubMed)
Show all 3 Pubmed References

More Antibodies against HMGCS2 Interaction Partners

Human 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

Canonical pathway analysis, using Ingenuity Pathway Analysis software, revealed that the only genes in the "superpathway of cholesterol biosynthesis" were Idi1 (upregulated) and Hmgcs2 (downregulated). The Idi1 and Hmgcs2 genes have regulatory roles in atrial lipotoxic myopathy associated with atrial enlargement
Our data also suggested that apart from heart, the expression of HMGCS2 was also different in kidney and spleen between control and STZ treated mice. In conclusion, The HMGCS2 molecule may potentially be involved in T1D induced cardiac dysfunction.
several nutrients as well as specific nutritional related hormonal conditions are able to affect significantly HMGCS2 gene expression.
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in Src expression and activation in a metabolically independent manner
HMGCS2 shares with ketone bodies common features in autophagic clearance of APP, suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).
An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression
The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

To elucidate the relationship between HMGCS2 and NF-kB, we tested inhibited and over-expressed NF-kB. We found that NF-kB acted as a positive regulator for HMGCS2 under ketosis treatment conditions.
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 enhances ketogenesis through HMGCS2 signaling activation by p38/NF-kB p65.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8-/- mice.

HMGCS2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) antibody
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2) antibody
hydroxymethylglutaryl-CoA synthase (mvaS) antibody
hydroxymethylglutaryl-CoA synthase (CNC05080) antibody
hydroxymethylglutaryl-coa synthase (HMCS1) antibody
hydroxymethylglutaryl-CoA synthase (hgsA) antibody
hydroxymethylglutaryl-CoA synthase (MFER_RS00425) antibody
hydroxymethylglutaryl-CoA synthase (LOC100285783) antibody
3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 (ECU10_0510) antibody
3-hydroxy-3-methylglutaryl-CoA synthase 2 (Eint_100450) antibody
3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) antibody

1300002P16 antibody
DDBDRAFT_0219349 antibody
DDBDRAFT_0219924 antibody
DDB_0219349 antibody
DDB_0219924 antibody
hmgCoA antibody
Hmgcs1 antibody
mHS antibody
Mt3h3mg antibody

Protein level used designations for HMGCS2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) , HMG-CoA synthase , hydroxymethylglutaryl-CoA synthase, mitochondrial , 3-hydroxy-3-methylglutaryl coenzyme A synthase , 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) , hydroxymethylglutaryl-CoA synthase 2 , hydroxymethylglutaryl-CoA synthase, mitochondrial-like , hydroxymethylglutaryl-CoA synthase , hydroxymethylglutaryl-coa synthase , GRMZM2G106263 , putative hydroxymethylglutaryl-CoA synthase family protein , 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 , 3-hydroxy-3-methylglutaryl-CoA synthase 2 , 3-hydroxy-3-methylglutary-Coenzyme A synthase 2

GENE ID	SPECIES
3158	Homo sapiens
15360	Mus musculus
100343479	Oryctolagus cuniculus
100449449	Pongo abelii
100484975	Ailuropoda melanoleuca
2798767	Listeria monocytogenes serotype 4b str. F2365
3256225	Cryptococcus neoformans var. neoformans JEC21
7446804	Thalassiosira pseudonana CCMP1335
8626645	Dictyostelium discoideum AX4
9961791	Methanothermus fervidus DSM 2088
100285783	Zea mays
100059971	Equus caballus
100581170	Nomascus leucogenys
859815	Encephalitozoon cuniculi GB-M1
9699436	Encephalitozoon intestinalis ATCC 50506
24450	Rattus norvegicus
503684	Bos taurus
424380	Gallus gallus
607923	Canis lupus familiaris
397673	Sus scrofa
100727078	Cavia porcellus

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Show all anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Antibodies with Pubmed References

Human 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) interaction partners

Antigen Summary

Alternative names and synonyms associated with HMGCS2

Protein level used designations for HMGCS2