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Full name:: UDP-Galactose-4-Epimerase Proteins (GALE)

On www.antibodies-online.com are 30 UDP-Galactose-4-Epimerase (GALE) Proteins from 11 different suppliers available. Additionally we are shipping GALE Antibodies (73) and GALE Kits (3) and many more products for this protein. A total of 115 GALE products are currently listed.

Synonyms:: 1n569, 2310002A12Rik, AI323962, BA5505, BA5700, ECK0748, F15H21.11, F15H21_11, galD, galE, im:7147391, JW0742, REB1, ROOT EPIDERMAL BULGER1, ROOT HAIR DEFECTIVE 1, SDR1E1, SMU.888, UDP-GLUCOSE 4-EPIMERASE, UGE4, VFA0352, wu:fb05f01, xgale, zgc:136578

list all proteins	Gene Name	GeneID	UniProt
	GALE	74246	Q8R059
	GALE	2582	Q14376
	GALE	114860
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Arabidopsis thaliana UDP-Galactose-4-Epimerase (GALE) interaction partners

This data from this study indicate the importance of UDP-D-galactose synthesis by UGE4 for the organization and function of endomembranes, especially TGN (show TG Proteins)/EEs, which are a sorting station of the secretory and vacuolar pathways.
Rough mapping and whole-genome sequencing identified the mutant with altered localization of NIP5;1 as an allele of UDP-glucose 4-epimerase 4.
RHD1, a UDP-glucose-4-epimerase, is a likely target of root-specific negative regulation by ethylene and that loss of RHD1 function results in a heightened sensitivity of root tissues to both ethylene and auxin. [RHD1]
UGE2 and UGE4 influence growth and cell wall carbohydrate biosynthesis throughout the plant, UGE3 is specialized for pollen development, and UGE1 and UGE5 might act in stress situations.

Mouse (Murine) UDP-Galactose-4-Epimerase (GALE) interaction partners

These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 (show TFF3 Proteins) expression.
results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes.

Human UDP-Galactose-4-Epimerase (GALE) interaction partners

Mutation in UDP-galactose-4'-epimerase gene is associated with UDP-galactose-4'-epimerase deficiency.
Data show the protein structure of GALE and its substrate binding and specificity. It is mutated in type III galactosemia. [review]
human UDP-galactose 4'-epimerase stability is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding
These data indicated a critical role of GALE in maintaining cartilage homeostasis, and suggested that GALE inhibition might contribute to OA progress.
GALE variants can be arranged into three groups depending on the severity of enzyme impairment.
Resulst describe the relationship among UDP-galactose 4'-epimerase activity, substrate specificity, metabolic balance, and galactose sensitivity in mammalian cells.
Subtle biochemical and metabolic abnormalities detected in patients expressing these GALE alleles likely reflect, at least in part, the reduced enzymatic activity of the encoded GALE proteins.
Our observations show that altered protein stability is due to misfolding and that loss or reduction of enzyme activity is responsible for the molecular defects underlying GALE-deficiency galactosemia.

GALE Protein Profile

Protein Summary

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Alternative names and synonyms associated with GALE

UDP-galactose-4-epimerase (GALE)
UDP-galactose-4-epimerase (gale)
NAD(P)-binding Rossmann-fold superfamily protein (RHD1)
UDP-galactose-4-epimerase (ECs0787)
UDP-galactose-4-epimerase (galE)
UDP-galactose 4-epimerase GalE (galE)
UDP-glucose 4-epimerase (galE1)
UDP-glucose 4-epimerase (galE2)
UDP-glucose 4-epimerase GalE (galE)
UDP-glucose 4-epimerase (STY0809)
UDP-glucose 4-epimerase (galE)
UDP-glucose/UDP-N-acetylglucosamine 4-epimerase (galE)
UDP-glucose 4-epimerase (galE-2)
UDP-galactose-4-epimerase (SG0897)
UDP-galactose-4-epimerase (galD)
UDP-galactose-4-epimerase (Ent638_1250)
galactose-4-epimerase, UDP (Gale)
UDP-galactose-4-epimerase L homeolog (gale.L)
UDP-galactose-4-epimerase (Gale)

1n569 protein
2310002A12Rik protein
AI323962 protein
BA5505 protein
BA5700 protein
ECK0748 protein
F15H21.11 protein
F15H21_11 protein
galD protein
galE protein
im:7147391 protein
JW0742 protein
REB1 protein
ROOT EPIDERMAL BULGER1 protein
ROOT HAIR DEFECTIVE 1 protein
SDR1E1 protein
SMU.888 protein
UDP-GLUCOSE 4-EPIMERASE protein
UGE4 protein
VFA0352 protein
wu:fb05f01 protein
xgale protein
zgc:136578 protein

Protein level used designations for GALE

UDP-galactose-4-epimerase , UDP-glucose 4-epimerase , fb05f01 , UDP-galactose 4-epimerase , galactowaldenase , UDP-glucose (37.7 kD) (1N569) , UDP galactose-4'-epimerase , galactose-4-epimerase, UDP- , short chain dehydrogenase/reductase family 1E, member 1 , galactose-4-epimerase, UDP

GENE ID	SPECIES
419686	Gallus gallus
456623	Pan troglodytes
678540	Danio rerio
842752	Arabidopsis thaliana
917525	Escherichia coli O157:H7 str. Sakai
945354	Escherichia coli str. K-12 substr. MG1655
957904	Escherichia coli O157:H7 str. EDL933
1028251	Streptococcus mutans UA159
1036650	Escherichia coli CFT073
1067209	Salmonella enterica subsp. enterica serovar Typhi str. Ty2
1085150	Bacillus anthracis str. Ames
1085447	Bacillus anthracis str. Ames
1147990	Yersinia pestis KIM10+
1169457	Shewanella oneidensis MR-1
1173989	Yersinia pestis CO92
1247256	Salmonella enterica subsp. enterica serovar Typhi str. CT18
1252296	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2687202	Geobacter sulfurreducens PCA
2763289	Yersinia pestis biovar Microtus str. 91001
2883164	Pectobacterium atrosepticum SCRI1043
2955669	Yersinia pseudotuberculosis IP 32953
3103661	Methylococcus capsulatus str. Bath
3231780	Campylobacter jejuni RM1221
3280601	Vibrio fischeri ES114
3728483	Carboxydothermus hydrogenoformans Z-2901
3779874	Shigella boydii Sb227
3868345	Sodalis glossinidius str. 'morsitans'
4714920	Yersinia enterocolitica subsp. enterocolitica 8081
5114212	Enterobacter sp. 638
74246	Mus musculus
380596	Xenopus laevis
2582	Homo sapiens
523154	Bos taurus
114860	Rattus norvegicus
487373	Canis lupus familiaris

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