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CD9 (show CD9 Proteins) stabilizes gp130 (show IL6ST Proteins) by blocking its ubiquitin-dependent lysosomal degradation to promote the IL6 (show IL6 Proteins)-gp130 (show IL6ST Proteins)-bone marrow X-linked non-receptor tyrosine kinase (show TNK1 Proteins)-STAT3 (show STAT3 Proteins) signaling for maintaining GSC (show GSC Proteins) selfrenewal and tumorigenic capacity.
CD9 (show CD9 Proteins) was highly expressed on extravillous trophoblast (EVT) at the boundary region of EVT invasion and intravascular EVT. CD9 (show CD9 Proteins) expression on Swan71 cells was reduced under hypoxic conditions, while its expression was increased by co-culture with HUVEC. CD9 (show CD9 Proteins) could attenuate EVT invasion under the influence of an oxygen environment and maternal endothelial cells, proposing CD9 (show CD9 Proteins) as a potential regulator of human placentation.
As for 18Lin(-), CD34 (show CD34 Proteins)(-) HSCs are characterized by low expression of the tetraspanin CD9 (show CD9 Proteins), which promotes homing, and high expression of the peptidase CD26 (show DPP4 Proteins), which inhibits homing.
The findings suggest that, in contrast with previous models, the ligand-binding site of integrin alphaVbeta3 (show ITGAV Proteins), binds to the constant region (helices A and B) of the EC2 (show TCF15 Proteins) domain of CD9 (show CD9 Proteins), CD81 (show CD81 Proteins), and CD151 (show CD151 Proteins) antigens.
Data suggest that CD9 (show CD9 Proteins) should be further evaluated as a target for glioblastoma treatment.
Collectively, using tetraspanin CD9 (show CD9 Proteins) in tandem with E-cadherin (show CDH1 Proteins) as a biomarker in renal cell carcinoma (show MOK Proteins) will help to not only distinguish between types, but also predict the metastatic potential of RCC (show XRCC1 Proteins).
Data indicate that CD9 (show CD9 Proteins) is implicated in BCC invasiveness and metastases by cellular mechanisms that involve specific CD9 (show CD9 Proteins)+ plasma membrane protrusions of BCCs.
CD9 (show CD9 Proteins)-enriched microdomains negatively regulate LPS (show IRF6 Proteins)-induced receptor formation by preventing CD14 (show NDUFA2 Proteins) from accumulating into lipid rafts. [Review]
Results indicate that CD9 (show CD9 Proteins) downregulation promoted pancreatic cancer cell proliferation and migration through at least in part, enhancing the cell surface expression of EGFR (show EGFR Proteins).
CD9 (show CD9 Proteins) expression is upregulated and its expression is correlated with tumor stage and lymph node metastasis in esophageal squamous cell carcinoma patients
Mice lacking RXRalpha (show RXRA Proteins) in myeloid cells exhibit reduced levels of CCL6 (show CCL6 Proteins) and CCL9 (show Ccl9 Proteins), impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
enhanced expression in intestinal epithelium following immunostimulation with LPS (show TLR4 Proteins) or pro-inflammatory cytokines
the injury-induced expression of C10 (show C12orf57 Proteins) at the mRNA and protein level
c10 (show C12orf57 Proteins) promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung
CCL6 (show CCL6 Proteins) gene activation and production induced by SCF (show KITLG Proteins) in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK (show MDK Proteins)/MAPK (show MAPK1 Proteins) pathway but not the PI-3K pathway was crucial for the SCF (show KITLG Proteins)-induced CCL6 (show CCL6 Proteins) gene activation.
the chemokines CCL6 (show CCL6 Proteins) and CCL9 (show Ccl9 Proteins) as genes prominently induced by the type I IFNs and ICSBP (show IRF8 Proteins)
This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis.
ATP-binding cassette sub-family C ( CFTR/MRP) member 1a
, ATP-binding cassette sub-family C member 1
, ATP-binding cassette, sub-family C (CFTR/MRP), member 1
, LTC4 transporter
, leukotriene C(4) transporter
, multidrug resistance protein 1
, multidrug resistance-associated protein 1
, multiple drug resistance-associated protein
, 5H9 antigen
, BA-2/p24 antigen
, CD9 antigen
, CD9 antigen (p24)
, cell growth-inhibiting gene 2 protein
, leukocyte antigen MIC3
, motility related protein-1
, C-C motif chemokine 6
, CC chemokine C10
, small inducible cytokine A6
, small-inducible cytokine A6