Browse our PITX2 Proteins (PITX2)

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

• paired like homeodomain 2 (PITX2)
• paired-like homeodomain transcription factor 2 (Pitx2)
• paired-like homeodomain 2 (pitx2)
• paired-like homeodomain 2 (Pitx2)
• paired like homeodomain 2 S homeolog (pitx2.S)
• Show all gene names
• paired like homeodomain 2 (pitx2)
• paired like homeodomain 2 L homeolog (pitx2.L)
• paired like homeodomain 2 (Pitx2)

• 9430085M16Rik protein
• arp1 protein
• brx1 protein
• Brx1a protein
• Brx1b protein
• Show all synonym aliases
• idg2 protein
• igds protein
• igds2 protein
• ihg2 protein
• irid2 protein
• Munc30 protein
• otlx2 protein
• pitx-2 protein
• pitx2 protein
• pitx2-A protein
• pitx2a protein
• Pitx2b protein
• pitx2c protein
• Pitx2cbeta protein
• ptx2 protein
• rgs protein
• rieg protein
• rieg1 protein
• RS protein
• xpitx2 protein
• xPtx2 protein
• XPtx2b protein
• zgc:110508 protein

ALL1-responsive protein ARP1 , all1-responsive gene 1 , homeobox protein PITX2 , paired-like homeodomain transcription factor 2 , pituitary homeobox 2 , rieg bicoid-related homeobox transcription factor 1 , solurshin , BRX1 homeoprotein , orthodenticle-like homeobox 2 , paired-like homeodomain transcription factor Munc 30 , paired-like homeodomain transcription factor 2a , pitx2b , homeodomain transcription factor 2 , rPtx2 , cPITX2 , transcription factor Pitx2 , homeodomain transcription factor Pitx2