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This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
pancreas specific transcription factor, 1a
, bHLH transcription factor p48
, pancreas transcription factor 1 subunit alpha
, pancreas-specific transcription factor 1a
, Pancreas-specific transcription factor 1a
, transcription factor Ptf1a/p48
, class A basic helix-loop-helix protein 29
, class II bHLH protein PTF1A
, exocrine pancreas-specific transcription factor p48
, p48 DNA-binding subunit of transcription factor PTF1
, pancreas transcription factor1 p48 subunit