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Data suggest that BICD1 and BICD2 are highly expressed in the nervous system during development and are important in neuronal homeostasis. [REVIEW]
This study showed that rs2735940 hTERT CX-TT donor-recipient genotype pair was associated with almost five times higher odds (OR=4.82; 95% CI: 1.32-18; p=0.016) of delayed graft function (DGF), and that rs2735940 hTERT, rs2630578 BICD1, and rs7235755 chromosome 18 polymorphisms combined pairs were not associated with acute rejection (AR).
Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation.
Graft BICD1 polymorphisms apart from the association with telomere length, affect early kidney function after transplantation
Variants in BICD1 are associated with length of telomeres, which suggests that a mechanism linked to accelerated aging may be involved in the pathogenesis of emphysema.
the protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization
Various processes in which BicD is involved during Drosophilian development (review)
findings show BICD1 localized to Chlamydia trachomatis inclusions in a biovar-specific manner and that EGFP-BICD1 is recruited to the inclusion in a microtubule- and Golgi apparatus-independent but chlamydial gene expression-dependent mechanism
These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization.
The brain-specific (show CALY Proteins) Rab6B (show RAB6B Proteins) via Bicaudal-D1 is linked to the dynein/dynactin (show DCTN1 Proteins) complex, suggesting a regulatory role for Rab6B (show RAB6B Proteins) in the retrograde transport of cargo in neuronal cells.
findings suggest a molecular basis for cargo recognition and autoinhibition of BICD proteins during dynein-dependent intracellular retrograde transport
BICD1 regulates neurotrophin (show BDNF Proteins) signalling by modulating the endosomal sorting of internalised ligand-activated receptors.
Impairment of retrograde transport by knockdown of DHC1 (show DYNC1H1 Proteins) or BicD1 inhibits stress-granule formation and P-body growth upon stress.
This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.
bicaudal D homolog 1
, bic-D 1
, cytoskeleton-like bicaudal D protein homolog 1
, protein bicaudal D homolog 1