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Study present a 2.7-A crystal structure of the catalytic domain of human NOCT. Our structure shows that NOCT has a close overall similarity to CCR4 deadenylase family members, PDE12 and CNOT6L, and to a DNA repair enzyme TDP2. All the key catalytic residues present in PDE12, CNOT6L and TDP2 are conserved in NOCT and have the same conformations.
NOCT is an exoribonuclease that can degrade mRNAs to inhibit protein expression
This review seeks to integrate these new discoveries into our understanding of Nocturnin's regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.
results highlight the clinical significance of PARN and NOC on the survival in SCC diagnosed patients.
Three tag SNPs (rs938836, rs17050680, rs3805213) in the CCRN4L are significant correlation with genotype and allele frequency in lung cancer.
Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.
Ccr4d functions as an anti-proliferating protein through the induction of cell cycle arrest via a p21-dependent and p53-independent pathway and suggest that Ccr4d might have an important role in carcinogenesis.
A human lung cancer cell line SBC-5 that efficiently metastasized to bone when intravenously injected into SCID mice was found to express CCR4.
The transcription of human nocturnin gene displayed circadian oscillations in Huh7 cells (a human hepatoma cell line) and was regulated by CLOCK/BMAL1 heterodimer via the E-box of nocturnin promoter.
posttranscriptional control by Nocturnin regulates the amplitude of critical metabolic pathways, and loss of this activity results in increased metabolic flux and reduced obesity
Data suggest that Nocturnin (NOC) exerts strong effects on physiology through direct and indirect control of target mRNAs.
precise expression of nocturnin is critical to proper development of early mouse embryos
Nocturnin plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes
data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals
Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate.
Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids.
Noc interacts with Igf1 in a strain- and tissue-specific manner and reduces Igf1 expression by targeting the longer form of the Igf1 3'UTR.
Noc plays a unique role in the regulation of mesenchymal stem-cell lineage allocation by modulating PPAR-gamma activity through nuclear translocation.
Nocturnin, is markedly upregulated with Pparg activation in adipocytes and bone marrow stromal cells.
nocturnin exhibits circadian rhythmicity of mRNA abundance with peak levels at the time of light offset in the retina, spleen, heart, kidney and liver.
circadian expression in the liver and retina
Nocturnin expression can be regulated by extracellular stimuli, it can respond directly and specifically to physiological cues
Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity.
A similar protein in Xenopus laevis was shown to be a deadenylase (mRNA poly A ribonuclease).
We found that the amino acid sequences of zebrafish nocturnin-a and nocturnin-b are highly similar to those of frog, mouse, and human nocturnin homologs. Only nocturnin-b is expressed in the eye. Within the retina, nocturnin-b mRNA was expressed at higher levels in the retinal photoreceptors layer than in other cellular layers. This expression pattern echoes the restricted photoreceptor expression of nocturnin in the fro
Data suggest that nocturnin deadenylates clock-related transcripts in a novel mechanism for posttranscriptional regulation in the circadian clock or its outputs.
nocturnin is a circadian clock-regulated gene identified by differential display
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.
CCR4 protein homolog
, CCR4-like (carbon catabolite repression 4, S.cerevisiae)
, CCR4 carbon catabolite repression 4-like
, carbon catabolite repression 4 homolog
, CCR4 carbon catabolite repression 4-like B
, carbon catabolite epression 4 homolog
, CCR4 carbon catabolite repression 4-like, nocturnin
, rhythmic message 1