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Studies suggest that eukaryotic initiation factor (show EIF4G1 Proteins) eIF3, which coordinates the progress of most of the initiation steps, does not come off the initiation complex upon subunit joining, but instead it remains bound to 80S ribosomes.
DHX29 (show DHX29 Proteins) and eIF3 cooperate in scanning on structured mRNAs. Our findings support previous genetic data on the role of eIF3 during scanning
interaction involves the first FF motif of p190A (show GRLF1 Proteins) and the winged helix/PCI (show SERPINA5 Proteins) domain of eIF3A (show EIF6 Proteins), is enhanced by serum stimulation and reduced by phosphatase treatment
The eIF3a (show EIF6 Proteins) Arg803Lys C>T polymorphism is connected with a higher susceptibility to cervical carcinoma and may affect chemoradiotherapy efficacy in and prognosis of cervical carcinoma.
The human eIF3b (show EIF3B Proteins) and octameric eIF3a (show EIF6 Proteins) subunits serve as the nucleation core around which other subunits assemble in an ordered way into two interconnected modules: the yeast-like core and the octamer.
eIF3a (show EIF6 Proteins) may function as a novel regulator to modulate hepatic stellate cell activation, potentially through inhibiting the TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) signaling pathway.
Collybistin (show Arhgef9 Proteins) forms a complex with mTOR (show FRAP1 Proteins) and eIF3 and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism.
eIF3 has a role in controlling cell size independently of S6K1 (show RPS6KB1 Proteins)-activity
eIF3a (show EIF6 Proteins) improves ovarian cancer patients' response to cisplatin-based chemotherapy by down regulating XPC (show XPC Proteins) and p27(Kip1 (show CDKN1B Proteins)).
eIF3a (show EIF6 Proteins) SNPs are significantly correlated with platinum-based chemotherapy toxicities in Chinese non-small cell lung carcinoma patients.
The pleiotropic mouse phenotype extra-toes spotting (show EIF3C Proteins) is caused by translation initiation factor (show TIF1 Proteins) Eif3c (show EIF3C Proteins) mutations.
May play some roles in development and differentiation; decreased eIF3a expression may be a pre-requisite of intestinal epithelial cell differentiation.
Stable expression of a truncated eIF3e (show EIF3E Proteins) in NIH 3T3 cells causes malignant transformation
eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
, eukaryotic translation initiation factor 6
, Eukaryotic translation initiation factor 3 subunit 10
, eukaryotic translation initiation factor 3 subunit 10
, eukaryotic translation initiation factor 3 subunit A
, EIF3, p180 subunit
, centrosomin homolog
, cytoplasmic protein p167
, eIF3 p167
, eIF3 p180
, eIF3 p185
, eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)
, eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)
, eukaryotic translation initiation factor 3, subunit 10, 170kD
, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167) (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN)
, eukaryotic translation initiation factor 3, subunit 10 (theta)