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Partial silencing of RPS14 inhibits the proliferation of SKM-1, an acute myeloid leukemia (show BCL11A Proteins) cell line, and RPS14 negatively regulates p53 (show TP53 Proteins) activation in SKM-1 cells.
RPS14 stabilized and activated p53 (show TP53 Proteins) by inhibiting HDM2-mediated p53 (show TP53 Proteins) polyubiquitination and degradation
Patients with nonclassical Diamond Blackfan anemia and other hypoproliferative anemias may have somatically acquired 5q deletions with RPS14 haploinsufficiency
Data indicate that RPS14 negates c-Myc (show MYC Proteins) functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA.
lower RPS14 predicts prolonged survival and possible response to lenalidomide in lower risk MDS (show PAFAH1B1 Proteins) patients.
RPS14 and RPS19 (show RPS19 Proteins) have distinct roles in regulating the MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins) feedback loop in response to ribosomal stress
Loss of RPS14 is associated with 5q-syndrome.
Combined loss of miR (show MLXIP Proteins)-145 and RPS14 cooperates to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome.
Myelodysplactic syndrome patients with an intermediate-1 risk score and low RPS14 expression have a superior median overall survival compared to patients with high RPS14 expression.
p53 (show TP53 Proteins) accumulates selectively in the erythroid lineage in primary human hematopoietic progenitor cells after expression of shRNAs targeting RPS14, the ribosomal protein gene deleted in the 5q-syndrome, or RPS19 (show RPS19 Proteins).
Rps14 haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8 (show S100A8 Proteins)-S100A9 (show S100A9 Proteins) expression, leading to a p53 (show TP53 Proteins)-dependent erythroid differentiation defect.
ribosomal protein RPS-14 is able to modulate let-7 function in C. elegans
p53 (show TP53 Proteins) synthesis is affected in zebrafish tumors with ribosomal protein gene mutations
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
40S ribosomal protein S14
, emetine resistance
, ribosomal protein S14
, ribosomal protein S14b