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Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator (show PTBP2 Proteins) SRP55; SRP55-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM (show BCL2L11 Proteins), BAX (show BAX Proteins)), JNK (show MAPK8 Proteins) signaling, and endoplasmic reticulum stress. (BIM (show BCL2L11 Proteins) = BCL-2 interacting protein BIM (show BCL2L11 Proteins); BAX (show BAX Proteins) = apoptosis regulator BAX (show BAX Proteins))
The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease.
LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic.
The authors propose that splicing at 3'ss A3 is dependent on binding of the enhancing SR proteins SRSF2 and SRSF6 to the HIV-1 tat ESE and ESE2 sequence.
SRSF6 is a regulator of wound healing and tissue homeostasis in skin.
Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS.
The splicing factor (show SLU7 Proteins) SRSF6 is an oncoprotein that regulates the proliferation and survival of lung and colon cancer cells.
Phosphorylation of SRp55 by Dyrk1A (show DYRK1A Proteins) suppressed its ability to promote Tau exon 10 inclusion.
Report upregulation of Bim (show BCL2L11 Proteins) and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF (show BRAF Proteins) inhibitors.
SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs.
Nova1 (show NOVA1 Proteins) isoforms exhibited differential effects on repressing the development of BAs. Moreover, overexpression of Nova1 (show NOVA1 Proteins) proteins reduced the serine/arginine splicing factor (show SLU7 Proteins) 6 (SRSF6) level by enhancing the generation of intron 2-included (SRSF6(+intron 2)) transcripts
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.
splicing factor, arginine/serine-rich 6
, SR splicing factor 6
, pre-mRNA-splicing factor SRP55
, splicing factor, arginine/serine-rich, 55 kDa
, arginine/serine-rich splicing factor 6
, splicing factor, arginine/serine-rich 6b