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PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 (show TPM4 Proteins) Sertoli cells via the p53 (show TP53 Proteins)/Bcl-2 (show BCL2 Proteins)/caspases signaling pathway.
Meta-analysis of genome-wide association studies identifies a novel variant in PRPS2 on Xp22.3 as susceptibility locus for systemic lupus erythematosus.
The expression of different genes encoding subunits of PRPS (show MSMB Proteins) enzyme is affected by hypoxia in tumor glioma cells, but the effect of hypoxia is modified by suppression of endoplasmic reticulum stress signaling enzyme ERN1 (show ERN1 Proteins).
Analysis of in vivo C-MYC (show MYC Proteins) interactions with TS, IMPDH2 (show IMPDH2 Proteins) and PRPS2 genes confirmed that they are direct C-MYC (show MYC Proteins) targets.
Study demonstrates with a Prps2 knockout mouse that the nexus between protein and nucleotide biosynthesis controlled by PRPS2 is crucial for Myc (show MYC Proteins)-driven tumorigenesis.
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants.
, Phophoribosylpyrophosphate synthetase, subunit II
, phosphoribosyl pyrophosphate synthase II
, phosphoribosyl pyrophosphate synthetase II
, ribose-phosphate pyrophosphokinase 2
, PPRibP synthetase
, ribose-phosphate diphosphokinase 2