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Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria.
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The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer
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OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes.
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The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer
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[review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity
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OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU.
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High expression levels of orotate phosphoribosyl transferase and thymidylate synthase in colorectal cancer appear to be significantly involved in metastasis after curative surgery
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Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS.
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novel phosphoribosyltransferase transition states
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orotate phosphoribosyl transferase/DPD ratio has a relation to cancer staging and survival rate.
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Increased orotate phosphoribosyltransferase expression is associated with bladder cancers.
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expression of OPRT gene and the OPRT/dihydropyrimidine dehydrogenase ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
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thymidylate synthase and orotate phosphoribosyl transferase, but not dihydropyrimidine dehydrogenase, are more highly expressed in prostate cancer than in benign prostatic hyperplasia
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orotate phosphoribosyl transferase has a role in lymph node metastasis of gastric cancer
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The investigated SNPs of OPRT may have no major influence on 5-FU sensitivity.
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The OPRT Gly213Ala polymorphism seems to be a useful marker for predicting toxicity to bolus 5-FU chemotherapy.
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Overexpression of the OPRT gene plays an important role in the antiproliferative effect of 5-FU.
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High expression of OPRT is associated with the response to adjuvant chemotherapy in human pancreatic cancer
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data suggest that OPRT is involved in early events of pancreatic and gallbladder carcinogenesis and invasion of hepatocellular carcinomas
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decreased the sensitivities of the cultured tumor cells to 5-FU. These results suggest that the OPRT expression level in tumors is an additional determinant of the efficacy of 5-FU.
