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anti-Human EPGN Antibodies:
anti-Mouse (Murine) EPGN Antibodies:
anti-Rat (Rattus) EPGN Antibodies:
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Study shows how the EGFR (show EGFR Antibodies) ligands epiregulin (EREG (show EREG Antibodies)) and epigen (EPGN) stabilize different dimeric conformations of the EGFR (show EGFR Antibodies) extracellular region. Results reveal how responses to different EGFR (show EGFR Antibodies) ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (show RET Antibodies) (RTK) signaling specificity.
EPG is an EGF (show EGF Antibodies)-like growth factor and a low affinity ligand
activation of the EGFR (show EGFR Antibodies) by its ligand epigen during early epidermal development causes hyperplasia of the sebaceous gland and, to a minor extent, hyperplasia of the interfollicular epidermis and increased hair follicles density.
Epigen has non-essential functions or functions that can be compensated by other EGFR (show EGFR Antibodies) ligands during growth and tissue homeostasis.
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants.
, epithelial mitogen homolog