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These results demonstrate a novel role for SORLA (show SORL1 Proteins) as a physiological and pathological EphA4 modulator.
The expression of both EphA4-FL and EphA4-N was significantly higher in the nervous tissue of SOD1 (show SOD1 Proteins)(G93A) compared to wild-type mice suggesting that both forms are modulated during the disease process.
the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins), Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathways as well as ERK1/2 downstream of EPHA4 receptor activation, play an important role in the regulation of events related with the EMT (show ITK Proteins) development, which may be associated with the therapeutic failure in rectal cancer after radiotherapy.
Molecular interactions of EphA4, growth hormone receptor (show GHR Proteins), Jak2 (show JAK2 Proteins), and STAT5B (show STAT5B Proteins) have been described.
Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling
Reduced EphA4 expression is associated with EBV-associated B lymphoma.
No difference was found in the expression of EPHA4 in morphologically normal glands, HGPIN, or prostatic cancer.
we supposed that EphA4 interacted with CDK5 (show CDK5 Proteins) and promoted its expression which in turn enhanced p-AKT (show AKT1 Proteins) expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.
EphA4 was reduced in breast carcinoma, which is associated with high grade, advanced TNM (show ODZ1 Proteins) stage, lymph node metastasis, and poor outcome of patients
Host EphA4 expression regulates cancer development mainly via EphA4-mediated IGF1 (show IGF1 Proteins) synthesis signal.
ephrin-B2 (show EFNB2 Proteins) and EphA4 have graded and modular expression patterns in the developing inferior colliculus
findings suggest a role for EphA4 in shaping cortical oscillations during sleep that is independent from sleep need
The present study demonstrates that EphA4 and EphA7 (show EPHA7 Proteins) receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
These results suggest that EphA4, a novel and promising target for treatment, exacerbates EBI (show TBL1X Proteins) through an Ephexin-1 (show NGEF Proteins)/ROCK2 (show ROCK2 Proteins) pathway after subarachnoid hemorrhage.
Our studies show that forward signaling through the EphA4 tyrosine kinase receptor (show KDR Proteins), mediated by ephrins expressed by subpopulations of neuroblasts and astrocytes, is required for compact, directional organization of neuroblasts and astrocytes within the pathway and efficient transit of neuroblasts through the anterior forebrain to the olfactory bulb.
Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
Delineation of the specific mutation in EphA4 in this strain is important for further functional studies, such as protein-protein interactions, immunostaining and gene compensatory studies, investigating the mechanism underlying the effects of altered function of Eph (show EPHA1 Proteins) family of receptor tyrosine kinases on phenotype.
expression of Eph (show EPHA1 Proteins) A1, A2, A4, and A7 was strongly detected in endometrial epithelial cells during early pregnancy.
The EphA4 gene is significantly associated with litter size in pigs.
EphA4-dependent Brachyury (show TBX1 Proteins) expression is required for dorsal mesoderm involution in the Xenopus gastrula.
show that EphA4 and its putative ligand, ephrin-A1 (show EFNA1 Proteins) are expressed in a complementary manner in the involuting mesodermal and non-involuting ectodermal layers of early gastrulae, respectively
Downregulation of EphA4a compromises actomyosin cables and cells with different rhombomeric identity intermingle, and the phenotype is rescued enhancing myosin II activity.
EphA4 (show EPHA3 Proteins) is required for cell adhesion and rhombomere-boundary formation in the zebrafish.
Data show that EfnB2a (show EFNB2 Proteins) is required in developing hindbrain for normal cell affinity and that EphA4 (show EPHA3 Proteins) and EfnB2a (show EFNB2 Proteins) regulate cell affinity independently within their respective rhombomeres.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
, EPH-like kinase 8
, TYRO1 protein tyrosine kinase
, ephrin type-A receptor 4
, receptor protein-tyrosine kinase HEK8
, tyrosine-protein kinase TYRO1
, tyrosine-protein kinase receptor SEK
, ephrin receptor epsilon
, EPH receptor A4
, ephrin receptor EphA4
, ephrin receptor EphA4-like
, ephrin type-A receptor 4-like
, tyrosine-protein kinase receptor MPK-3
, tyrosine-protein kinase receptor SEK-1
, ephrin type-A receptor 4-B
, receptor tyrosine kinase
, tyrosine-protein kinase receptor PAG
, eph receptor A3
, eph-like kinase 2
, eph-like receptor tyrosine kinase 1
, ephrin type-A receptor 4a
, tyrosine-protein kinase receptor ZEK2