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Here the authors show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2 (show IGF2 Proteins)) for the stabilization of presynaptic terminals.
FGF22 restores hearing loss after gentamycin treatment by maintaining ribbon synapse number, likely via inhibition of MEF2D (show MEF2D Proteins).
In FGF22 knock-out mice, presynaptically, the number of synaptic vesicles is reduced, along with bouton volume and reduced number of vesicles in axonal regions.
we examine how the two presynaptic organizers FGF22 and FGF7 (show FGF7 Proteins) are transported to the appropriate locations so that they act as synapse-type-specific organizing molecules.
FGF22 is a synaptogenic mediator in the adult nervous system and a crucial regulator of synapse formation and maturation during post-injury remodeling in the spinal cord.
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis
two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7 (show FGF7 Proteins), promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
Fgf22 has a potential role in cutaneous development and repair.
FGF22 is expressed by cerebellar granule cells during the period when they receive synapses. Its receptor, FGFR2 (show FGFR2 Proteins), is expressed by pontine neurons when they are making synapses on granule cells.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.
fibroblast growth factor 22