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anti-Human FGFR1 Antibodies:
anti-Mouse (Murine) FGFR1 Antibodies:
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Human Polyclonal FGFR1 Primary Antibody for FACS, IF - ABIN1882081
Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. in Archives of biochemistry and biophysics 2003
Show all 10 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for ELISA, WB - ABIN969138
Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. in The Journal of biological chemistry 2004
Show all 3 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN269474
Sasaki, Ishida, Toyota, Ota, Suzuki, Takaoka, Yasui, Yamamoto, Takagi, Maeda, Seito, Tsujisaki, Shinomura, Imai: Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. in PLoS ONE 2011
Show all 3 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN268017
Zhao, Frist, Yeoh, Miller: Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. in The Journal of clinical investigation 1994
Show all 3 Pubmed References
Human Polyclonal FGFR1 Primary Antibody for IHC (p), WB - ABIN3044410
Zhang, Zhang, Zhuang, Lu: Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. in Cancer biotherapy & radiopharmaceuticals 2006
Show all 2 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for ELISA, WB - ABIN966139
Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. in Arteriosclerosis, thrombosis, and vascular biology 2005
Show all 2 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN250617
Robinson, MacMillan-Crow, Thompson, Overbeek: Expression of a truncated FGF receptor results in defective lens development in transgenic mice. in Development (Cambridge, England) 1996
Human Polyclonal FGFR1 Primary Antibody for IHC (p), IHC - ABIN250368
Torry, Mukherjea, Arroyo, Torry: Expression and function of placenta growth factor: implications for abnormal placentation. in Journal of the Society for Gynecologic Investigation 2003
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN250616
Wang, Kan, McKeehan, Jang, Feng, McKeehan: A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor. in The Journal of biological chemistry 1997
Cow (Bovine) Polyclonal FGFR1 Primary Antibody for IHC (p), WB - ABIN4311478
Feng, Shao, Castro, Coleman, Nelson, Smith, Davies, Ittmann: Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors. in Oncotarget 2016
These results suggest that bFGF (show FGF2 Antibodies) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
in FGFR1 signalling JNK1 (show MAPK8 Antibodies) phosphorylation depends on ERK2 (show MAPK1 Antibodies)
Mactosylceramide, an early product in GSL (show CTSA Antibodies) biosynthesis, prevents inappropriate activation of insulin (show INS Antibodies) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (show MSH2 Antibodies), but does not require a differentiated visceral mesoderm.
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (show FGFR2 Antibodies) inhibitor or if Heartless function is missing from the neurons.
For the treatment of patients with breast cancer and FGFR1 amplifications.
presentation of the atomic structure of a 1:1:1 ternary complex that consists of the shed extracellular domain of alpha-klotho (show KL Antibodies), the FGFR1c ligand-binding domain, and FGF23 (show FGF23 Antibodies); in this complex, alpha-klotho (show KL Antibodies) simultaneously tethers FGFR1c by its D3 domain and FGF23 (show FGF23 Antibodies) by its C-terminal tail, thus implementing FGF23 (show FGF23 Antibodies)-FGFR1c proximity and conferring stability
Study identified FGFR1, a promoter of glycolysis-related enzyme, as the target of miR (show MLXIP Antibodies)-361 that promoted glycolysis and repressed oxidative phosphorylation in breast cancer cells. FGFR1 mediated the anti-glycolytic function of miR (show MLXIP Antibodies)-361 by regulating the activity of PDHK1 and LDHA (show LDHA Antibodies).
FGFR1 and/or FGF3 (show FGF3 Antibodies) gene amplification correlated with a lower pathologic complete response in patients with HER2 (show ERBB2 Antibodies)(+) early breast cancer treated with neoadjuvant anti-HER2 (show ERBB2 Antibodies) therapy.
Data demonstrated that FOXC1 (show FOXC1 Antibodies) binds to an Fgfr1 upstream regulatory region and that FOXC1 (show FOXC1 Antibodies) activates an Fgfr1 promoter element. Furthermore, elevated expression of Foxc1 (show FOXC1 Antibodies) led to increased Fgfr1-IIIc transcript promoting invasion after TGFbeta1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies).
These results suggest that FGFR1 gene amplification is a frequent alteration in squamous cell carcinoma of the lung and appears not to be a negative but rather a favorable prognostic marker for women and particularly for patients with advanced disease
These data suggest the ERalpha (show ESR1 Antibodies) pathway remains active in estrogen-deprived ER(+)/FGFR1-amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR (show FGFR2 Antibodies) antagonists.
Amplification of gene FGFR1 is associated with lung adenocarcinoma.
Lysosomal sequestration - resulting in an organelle-specific and pH-dependent nintedanib fluorescence - was identified as an intrinsic resistance mechanism in FGFR (show FGFR2 Antibodies)-driven lung cancer cells. Accordingly, combination of nintedanib with agents compromising lysosomal acidification (bafilomycin A1, chloroquine) exerted distinctly synergistic growth inhibitory effects
the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta (show TGFB1 Antibodies)/smad (show SMAD1 Antibodies) signaling and EndMT associated with MAP4K4 (show MAP4K4 Antibodies) phosphorylation (P-MAP4K4 (show MAP4K4 Antibodies)) in endothelial cells.
Suboptimal FGFR (show FGFR2 Antibodies) activation by a weak FGF1 (show FGF1 Antibodies)-FGFR (show FGFR2 Antibodies) dimer is sufficient to evoke a metabolic response, whereas full FGFR (show FGFR2 Antibodies) activation by stable and sustained dimerization is required to elicit a mitogenic response.
FGFR1 is a driver oncogene (show RAB1A Antibodies) in de novo, FGFR1-overexpressing acute myeloid leukemia (show BCL11A Antibodies)
Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (show CDC42 Antibodies) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (show MAPK1 Antibodies) cascades participate in osteogenesis, but only the ERK (show EPHB2 Antibodies) signaling pathway responds to FGFR1.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (show FGFR2 Antibodies) 2, in the oligodendr
data suggest that FGF2 (show FGF2 Antibodies) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Antibodies) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (show FGFR2 Antibodies), and FGFR3 (show FGFR3 Antibodies).
clearly demonstrate the different specificity of FGF12 (show FGF12 Antibodies)-FGFR1c2 and FGF22 (show FGF22 Antibodies)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
activation of FGFR1 and FGFR2 (show FGFR2 Antibodies) by uterine- and endometrial-derived FGF2 (show FGF2 Antibodies) stimulates PI3K/AKT (show AKT1 Antibodies) and mitogen-activated protein kinase (show MAPK1 Antibodies) pathways for development of the porcine uterus and improvement of litter size
Alterations in the expression of VEGF-A (show VEGFA Antibodies) and bFGF (show FGF2 Antibodies) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
mRNA and protein expression of FGFR-1, FGFR-2 (show FGFR2 Antibodies) in the porcine umbilical cord during pregnancy.
Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (show FGFR2 Antibodies) fgfr1 are expressed in normal and regenerating barbel tissue.
Shroom3 (show SHROOM3 Antibodies) is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (show FGFR2 Antibodies) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Antibodies) and its receptors, fgfr1 and fgfr4 (show FGFR4 Antibodies), using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
fibroblast growth factor receptor
, fibroblast growth factor receptor-1
, basic fibroblast growth factor receptor 1
, FGF receptor
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, basic fibroblast growth factor receptor 1-like
, FGFR1/PLAG1 fusion
, FMS-like tyrosine kinase 2
, fms-related tyrosine kinase 2
, heparin-binding growth factor receptor
, hydroxyaryl-protein kinase
, proto-oncogene c-Fgr
, FGF receptor-1
, cek1 protein
, tyrosine kinase receptor CEK1
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1-A