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anti-Human FGFR1 Antibodies:
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Human Polyclonal FGFR1 Primary Antibody for FACS, IF - ABIN1882081
Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. in Archives of biochemistry and biophysics 2003
Show all 10 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for ELISA, WB - ABIN969138
Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. in The Journal of biological chemistry 2004
Show all 3 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN268017
Zhao, Frist, Yeoh, Miller: Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. in The Journal of clinical investigation 1994
Show all 3 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN269474
Sasaki, Ishida, Toyota, Ota, Suzuki, Takaoka, Yasui, Yamamoto, Takagi, Maeda, Seito, Tsujisaki, Shinomura, Imai: Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. in PLoS ONE 2011
Show all 3 Pubmed References
Human Monoclonal FGFR1 Primary Antibody for ELISA, WB - ABIN966139
Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. in Arteriosclerosis, thrombosis, and vascular biology 2005
Show all 2 Pubmed References
Human Polyclonal FGFR1 Primary Antibody for IHC (p), WB - ABIN3044410
Zhang, Zhang, Zhuang, Lu: Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. in Cancer biotherapy & radiopharmaceuticals 2006
Show all 2 Pubmed References
Cow (Bovine) Polyclonal FGFR1 Primary Antibody for IHC (p), WB - ABIN4311478
Feng, Shao, Castro, Coleman, Nelson, Smith, Davies, Ittmann: Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors. in Oncotarget 2016
Human Polyclonal FGFR1 Primary Antibody for ELISA, WB - ABIN4311479
Weiss, Sos, Seidel, Peifer, Zander, Heuckmann, Ullrich, Menon, Maier, Soltermann, Moch, Wagener, Fischer, Heynck, Koker, Schöttle, Leenders, Gabler, Dabow, Querings, Heukamp, Balke-Want, Ansén, Rauh et al.: Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. ... in Science translational medicine 2010
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN250617
Robinson, MacMillan-Crow, Thompson, Overbeek: Expression of a truncated FGF receptor results in defective lens development in transgenic mice. in Development (Cambridge, England) 1996
Human Monoclonal FGFR1 Primary Antibody for CyTOF, FACS - ABIN250616
Wang, Kan, McKeehan, Jang, Feng, McKeehan: A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor. in The Journal of biological chemistry 1997
These results suggest that bFGF (show FGF2 Antibodies) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
in FGFR1 signalling JNK1 (show MAPK8 Antibodies) phosphorylation depends on ERK2 (show MAPK1 Antibodies)
Mactosylceramide, an early product in GSL (show CTSA Antibodies) biosynthesis, prevents inappropriate activation of insulin (show INS Antibodies) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (show MSH2 Antibodies), but does not require a differentiated visceral mesoderm.
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (show FGFR2 Antibodies) inhibitor or if Heartless function is missing from the neurons.
This study reveals a stringent association between FGFR (show FGFR2 Antibodies) and the downstream effector c-Myc (show MYC Antibodies) in FGFR (show FGFR2 Antibodies)-dependent cancers, and suggests the potential therapeutic value of c-Myc (show MYC Antibodies) in FGFR (show FGFR2 Antibodies)-targeted cancer therapy.
Elevated FGFR3 (show FGFR3 Antibodies) and FGFR1 protein expression is common in aggressive ependymomas but likely not driven by genetic alterations. Further studies are warranted to evaluate whether ependymoma patients with high FGFR3 (show FGFR3 Antibodies) and/or FGFR1 expression could benefit from treatment with FGFR (show FGFR2 Antibodies) inhibitor based therapeutic approaches currently under evaluation in clinical trials
These data identify FGFR1 as a driver gene in multiple soft-tissue sarcoma subtypes and support FGFR1 inhibition, guided by patient selection according to the FGFR1 expression and monitoring of MAPK (show MAPK1 Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) signaling, as a therapeutic option in this challenging group of diseases
Our results demonstrated that the AcSDKP-FGFR1 signaling pathway is critical for maintaining mitochondrial dynamics by control of miR (show MLXIP Antibodies) let-7b-5p in endothelial cells.
increased FGFR1 CN was observed in two racial groups not previously reported: African Americans and Native Americans. However, FGFR1 amplification is not prognostic in laryngeal squamous cell carcinomas
This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110 (show CCP110 Antibodies)-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase (show TXK Antibodies) inhibitor (TKI) dasatinib
Identify mutually exclusive activating hotspot mutations in FGFR1 and related PI-3K/RAS signaling genes in malignant phyllodes tumors which are implicated in tumor pathogenesis and/or progression.
we report FGFR1 as being frequently overexpressed in HNSCC and as a candidate prognostic biomarker in HPV-negative HNSCC.
Head and neck cancers are recurrently affected by FGFR1 amplification, with a predominance in cancers of the oral cavity.
High FGFR1 expression is associated with non-small cell lung cancer.
Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (show CDC42 Antibodies) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (show MAPK1 Antibodies) cascades participate in osteogenesis, but only the ERK (show EPHB2 Antibodies) signaling pathway responds to FGFR1.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (show FGFR2 Antibodies) 2, in the oligodendr
data suggest that FGF2 (show FGF2 Antibodies) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Antibodies) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (show FGFR2 Antibodies), and FGFR3 (show FGFR3 Antibodies).
clearly demonstrate the different specificity of FGF12 (show FGF12 Antibodies)-FGFR1c2 and FGF22 (show FGF22 Antibodies)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (show KLB Antibodies) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (show FGFR2 Antibodies)-betaKlotho (show KLB Antibodies) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.
Data suggest that Fgf1 (show FGF1 Antibodies)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (show FGF1 Antibodies)) and Fgfr1 (fibroblast growth factor receptor 1) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP Antibodies)).
activation of FGFR1 and FGFR2 (show FGFR2 Antibodies) by uterine- and endometrial-derived FGF2 (show FGF2 Antibodies) stimulates PI3K/AKT (show AKT1 Antibodies) and mitogen-activated protein kinase (show MAPK1 Antibodies) pathways for development of the porcine uterus and improvement of litter size
Alterations in the expression of VEGF-A (show VEGFA Antibodies) and bFGF (show FGF2 Antibodies) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
mRNA and protein expression of FGFR-1, FGFR-2 (show FGFR2 Antibodies) in the porcine umbilical cord during pregnancy.
Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (show FGFR2 Antibodies) fgfr1 are expressed in normal and regenerating barbel tissue.
Shroom3 (show SHROOM3 Antibodies) is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (show FGFR2 Antibodies) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Antibodies) and its receptors, fgfr1 and fgfr4 (show FGFR4 Antibodies), using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
fibroblast growth factor receptor
, fibroblast growth factor receptor-1
, basic fibroblast growth factor receptor 1
, FGF receptor
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, basic fibroblast growth factor receptor 1-like
, FGFR1/PLAG1 fusion
, FMS-like tyrosine kinase 2
, fms-related tyrosine kinase 2
, heparin-binding growth factor receptor
, hydroxyaryl-protein kinase
, proto-oncogene c-Fgr
, FGF receptor-1
, cek1 protein
, tyrosine kinase receptor CEK1
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1-A