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Human Neuregulin 1 Protein expressed in - ABIN1111470
Ng, Lee, Supko, Khan, Torres, Berwick, Ho, Kirkwood, Siegfried, Stabile: Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment. in Melanoma research 2014
Human Neuregulin 1 Protein expressed in Wheat germ - ABIN1307066
Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012
Human Neuregulin 1 Protein expressed in Human Cells - ABIN2004422
Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: Identification of heregulin, a specific activator of p185erbB2. in Science (New York, N.Y.) 1992
Show all 2 Pubmed References
We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor (show EGF Proteins)) or CD44 (show CD44 Proteins) (receptor-tyrosine-kinase (show ERBB3 Proteins) (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
Study found that the expression level of the neuregulin-1 (NRG1) protein was increased in the medial prefrontal cortex of fear-conditioned mice and manipulation of NRG1 activity in the prelimbic cortex affected fear-conditioning behaviors.
The manipulation of NRG1/ErbB4 (show ERBB4 Proteins) signaling in the present study revealed that NRG1/ErbB4 (show ERBB4 Proteins) activity in the hippocampus is critical for learning and memory.
Nrg1-I intramuscular injection enhanced muscle reinnervation by collateral sprouting
These results collectively suggest that sustained activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (show EGFR Proteins) signaling.
These results suggest that the neuropsin (show KLK8 Proteins)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB Proteins)-expressing interneurons, and that neuropsin (show KLK8 Proteins) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (show ERBB4 Proteins) signaling toward parvalbumin (show PVALB Proteins)-expressing interneurons.
we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 (show ERBB4 Proteins) activation in macrophages
Results show that at ventral hippocampus-nucleus accumbens synapses, presynaptic type III Nrg1 bidirectional signaling controls the establishment of ventral hippocampus-nucleus accumbens glutamatergic synapses. Type III Nrg1 back-signaling contributes to functional synaptic vesicle clustering and neurotransmitter vesicle release.
Results demonstrate for the first time a link between a mutation of a schizophrenia risk gene, neuregulin 1 and altered neuronal resonance properties in sensory cortex.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 (show ERBB4 Proteins) in regulating the initiation of critical period visual cortical plasticity.
NRG1-dependent activation of HER3 (show ERBB3 Proteins) induces primary resistance to trastuzumab in HER2 (show ERBB2 Proteins)-overexpressing breast cancer cells. HER3 (show ERBB3 Proteins) monoclonal antibody combined with trastuzumab may serve as a treatment choice for patients with primary resistance to trastuzumab.
Results represent the first comprehensive investigation of neuregulin-1 (NRG1) isoforms and protein expression in the blood of clozapine-treated schizophrenia patients and suggest levels of some NRG1 transcripts are upregulated in those with schizophrenia.
HRG/HER2 (show ERBB2 Proteins)/HER3 (show ERBB3 Proteins) signaling promotes AhR (show AHR Proteins)-mediated Memo-1 (show MEMO1 Proteins) expression and migration in colorectal cancer
Date indicate the subcellular localization and dynamics post-translational processing, (ectodomain shedding) of neuregulin1 (NRG1).
NRG1 and Gal-3 (show LGALS3 Proteins) were significantly more elevated in cancer patients than in healthy controls.
The toxicity profile of lumretuzumab in combination with cetuximab and erlotinib was manageable, but only modest clinical activity was observed across tumor types. In the sqNSCLC cohort, there was no evidence of meaningful clinical benefit despite enriching for tumors with higher HRG mRNA expression levels.
Using time-resolved-fluorescence energy transfer (TR-FRET), we demonstrated that in the presence of recombinant NRG1, binding of 9F7-F11 (show F11 Proteins) (a nonligand-competing anti-HER3 (show ERBB3 Proteins) antibody) to HER3 (show ERBB3 Proteins) is increased, whereas that of ligand-competing anti-HER3 (show ERBB3 Proteins) antibodies is decreased.
Data suggest that SLC3A2 (show SLC3A2 Proteins)-NRG1 should be considered a therapeutic target for patients with invasive mucinous adenocarcinoma of the lung (IMA).
we show that ErbB3 (show ERBB3 Proteins) interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 (show ERBB3 Proteins) to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3 (show ERBB3 Proteins).
NRG1 genotype is associated with substance use.
Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin (show AREG Proteins) [AREG (show AREG Proteins)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (show EGFR Proteins) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (show ERBB2 Proteins) and ErbB4 (show ERBB4 Proteins), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (show NOTCH1 Proteins) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (show EGF Proteins)-like ligand(s) activates the ErbB2 (show ERBB2 Proteins)/ErbB4 (show ERBB4 Proteins) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (show EGF Proteins) family member requirements for an evolutionary conserved process.
Notch1 (show NOTCH1 Proteins) activation induces expression of ephrin b2a (efnb2a (show EFNB2 Proteins)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (show NOTCH1 Proteins) activation in the absence of cardiac contraction rescues efnb2a (show EFNB2 Proteins) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (show ERBB3 Proteins) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (show DISC1 Proteins) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform