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Human Neuregulin 1 Protein expressed in Wheat germ - ABIN1307066
Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012
Human Neuregulin 1 Protein expressed in Human Cells - ABIN2004422
Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: Identification of heregulin, a specific activator of p185erbB2. in Science (New York, N.Y.) 1992
Show all 2 Pubmed References
Human Neuregulin 1 Protein expressed in - ABIN1111470
Ng, Lee, Supko, Khan, Torres, Berwick, Ho, Kirkwood, Siegfried, Stabile: Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment. in Melanoma research 2014
NOTCH1 (show NOTCH1 Proteins) signalling promotes extracellular matrix (ECM (show MMRN1 Proteins)) degradation during the formation of endocardial projections that are critical for individualization of trabecular units, whereas NRG1 promotes myocardial ECM (show MMRN1 Proteins) synthesis, which is necessary for trabecular rearrangement and growth.
Overexpression of neuregulin 1 alpha suppressed Nuclear forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) and its downstream targets, PEPCK (show PEPCK Proteins) and G6Pase (show G6PC Proteins) in liver and isolated hepatocytes.
Study shows that within endoplasmic reticulum-related subsurface cistern, sigma-1 receptors, Kv2.1 (show KCNB1 Proteins) and neuregulin-1 are clustered in highly specific, non-overlapping, microdomains, whereas ErbB2 (show ERBB2 Proteins) and ErbB4 (show ERBB4 Proteins) are present in the adjacent presynaptic compartment. This organization may define highly ordered and spatially restricted sites for different signal-transduction pathways.
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1), which acts on luminal cells via Erbb3 (show ERBB3 Proteins) and Erbb4 (show ERBB4 Proteins) receptors.
We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor (show EGF Proteins)) or CD44 (show CD44 Proteins) (receptor-tyrosine-kinase (show ERBB3 Proteins) (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
Study found that the expression level of the neuregulin-1 (NRG1) protein was increased in the medial prefrontal cortex of fear-conditioned mice and manipulation of NRG1 activity in the prelimbic cortex affected fear-conditioning behaviors.
The manipulation of NRG1/ErbB4 (show ERBB4 Proteins) signaling in the present study revealed that NRG1/ErbB4 (show ERBB4 Proteins) activity in the hippocampus is critical for learning and memory.
Nrg1-I intramuscular injection enhanced muscle reinnervation by collateral sprouting
These results collectively suggest that sustained activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (show EGFR Proteins) signaling.
These results suggest that the neuropsin (show KLK8 Proteins)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB Proteins)-expressing interneurons, and that neuropsin (show KLK8 Proteins) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (show ERBB4 Proteins) signaling toward parvalbumin (show PVALB Proteins)-expressing interneurons.
COMT (show COMT Proteins)-GG and NRG1-AA genotypes aid the transcranial direct current stimulation-induced improvement in auditory verbal hallucinations in schizophrenia patients.
The neuregulin1 was observed to be cleaved, adding to the 3 known NS3/4A cleavage targets. It showed that NS3/4A triggers an increase in neuregulin1 mRNA levels in HCV infected cells.
These results support the association between genetic variation of RET (show RET Proteins) and NRG1 and susceptibility to Hirschsprung disease in the Chinese population.
Results found that NRG1, a potential prognostic marker is highly expressed in papillary thyroid cancer (PTC (show F9 Proteins)). Also, further data demonstrate that NRG1 activates the antioxidant pathway by upregulating the expression of antioxidant enzymes through NRF2 (show GABPA Proteins), thus modulating redox homeostasis in PTC (show F9 Proteins).
Mesenchymal stem cell-drived paclitaxel resistance in ErbB2/ErbB3-coexpressing breast cancer cells could be attributed to upregulation of Survivin via paracrine effect of NRG-1/ErbB3/PI-3K/Akt signaling, as either specific knockdown expression of ErbB3, or blocking of downstream PI-3K/Akt signaling, or specific inhibition of Survivin can completely reverse this effect.
The data suggest a role for transcriptional regulation of NRG1 in the predisposition to papillary thyroid carcinoma.
NRG1rs3924999 and NRG1 rs6994992 are associated with change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment.
NRG1 is a potential prognostic and therapeutic biomarker in gastric cancer patients
Study found that the protein levels of NRG1 and ErbB4 (show ERBB4 Proteins) were significantly increased in the temporal cortex of patients with symptomatic epilepsy. Also, NRG1-ErbB4 (show ERBB4 Proteins) signaling suppresses GluN2B (show GRIN2B Proteins) phosphorylation by Src (show SRC Proteins) inhibition. GluN2B (show GRIN2B Proteins) is closely related to synaptic activity and its regulation by the NRG1-ErbB4 (show ERBB4 Proteins)-Src (show SRC Proteins) signaling axis highlights the importance of NRG1-ErbB4 (show ERBB4 Proteins) signaling in symptomatic epilepsy pathology.
Levels of NRG1 type III expression in peripheral blood mononuclear cells were positively correlated with impairments in social interaction in children with autism spectrum disorder.
Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin (show AREG Proteins) [AREG (show AREG Proteins)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (show EGFR Proteins) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (show ERBB2 Proteins) and ErbB4 (show ERBB4 Proteins), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (show NOTCH1 Proteins) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (show EGF Proteins)-like ligand(s) activates the ErbB2 (show ERBB2 Proteins)/ErbB4 (show ERBB4 Proteins) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (show EGF Proteins) family member requirements for an evolutionary conserved process.
Notch1 (show NOTCH1 Proteins) activation induces expression of ephrin b2a (efnb2a (show EFNB2 Proteins)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (show NOTCH1 Proteins) activation in the absence of cardiac contraction rescues efnb2a (show EFNB2 Proteins) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (show ERBB3 Proteins) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (show DISC1 Proteins) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform