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Meta-analysis found the levels of both NT-3 (show NTF3 Proteins) and NT-4/5 were significantly increased in bipolar disorder patients. Through subgroup analysis, this increase persisted only in patients in depressed state, but not in manic or euthymic state. In addition, we found the differences in NT-3 (show NTF3 Proteins) and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion.
Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations.
No differences in plasma BDNF, NGF, NT3, NT4 and GDNF were found between autism spectrum disorders and control.
Patients with mastocytosis featured elevated serum levels of NGF (show NGFB Proteins), NT-3 (show NTF3 Proteins), and NT-4. TrkA (show NTRK1 Proteins), TrkB (show NTRK2 Proteins), and TrkC (show NTRK3 Proteins) expression was also elevated.
The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients.
Studies indicate neurotrophin (show BDNF Proteins) family comprises nerve growth factor, brain-derived neurotrophic factor (show BDNF Proteins), neurotrophin-3 (show NTF3 Proteins) and neurotrophin-4 , and Zn(2+) and Cu(2+) interactions with them and modulate their activities through conformational changes.
NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis.
Suggest that a dysregulated TrkB (show NTRK2 Proteins)/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts.
neurotrophin 4 contributes to breast cancer cell survival and can serve as prospective target to inhibit tumor growth
In vitro follicular assembly is significantly increased in fetal ovaries cultured with NT-4.
This study provided evidence that NT-4 protein was presented in the mature bull spermatozoa and can influence the mitochondrial activity of bovine spermatozoa through TrkB tyrosine kinase (show NTRK2 Proteins)-dependent pathways.
Neurotrophin 4 may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins.
mast cell degranulation and NT4 release serve as upstream events that ultimately trigger long-lasting changes in airway smooth muscle innervation and function following early life insults. These findings suggest that blockade of mast cell degranulation may be a preventative strategy for young children at high risk of asthma.
BDNF (show BDNF Proteins) and NT4 play interchangeable roles in gustatory development.
Data indicate that BDNF, NT3 and NT4 trophic factors were detected in the conditioned medium of both wild-type and Friedreich's ataxia YG8 stem cells.
during early embryonic development, NT-4 produced in the ganglion and along the projection pathway inhibits cell death through an activated caspase-3 (show CASP3 Proteins) independent mechanism
The results of the present study demonstrate the post-transcriptional up-regulation of the Cav3.2 (show CACNA1H Proteins) T-current through TrkB (show NTRK2 Proteins) activation and identify NT-4 as a target-derived factor that regulates the mechanosensitive function of D-hair neurons.
the enhancing effects of treadmill training on axon regeneration include NT-4 5 in the proximal stump.
Findings indicate that NT4 functions at early embryonic stages and is derived from different sources than Bdnf (show BDNF Proteins).
Data show that gustatory neurons are equally dependent on BDNF (show BDNF Proteins) and NT-4 expression for survival, regardless of what peripheral target they innervate, but taste buds are more sensitive to BDNF (show BDNF Proteins) than NT-4 removal.
NT-4, alone or when co-expressed with brain-derived neurotrophic factor (show BDNF Proteins), is processed within and secreted by the constitutive secretory pathway
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
neurotrophin 5 (neurotrophin 4/5)
, neurotrophic factor 4
, neurotrophic factor 5
, neutrophic factor 4
, Neurotrophin 5 (neurotrophin 4/5)
, neurotrophin 4