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A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes Notch3 (show NOTCH3 Proteins)-driven leukemia development.
our data suggested that purpurogallin inhibits osteoclast differentiation via downregulation of c-Fos and NFATc1
the CD137 (show TNFRSF9 Proteins)-CD137L (show TNFSF9 Proteins) pathway plays an important role in regulating VSMC phenotype transformation via activation of NFATc1 signaling pathway.
Loss of NFATC1 is associated with Bone resorption.
Berberine hydrochloride targets TRAF6 (show TRAF6 Proteins) and NFATc1.
RCANs play critical roles in bone homeostasis by regulating both osteoclastogenesis and osteoblastogenesis, and they serve as inhibitors for calcineurin-NFATc1 signaling both in vivo and in vitro.
APC (show APC Proteins) defines Treg differentiation and anti-inflammatory function through microtubule-mediated NFAT localization.
Tusc2/Fus1 (show TUSC2 Proteins) regulates osteoclast differentiation through NF-kappaB (show NFKB1 Proteins) and NFATc1
these data demonstrated that wedelolactone facilitated osteoblastogenesis through Wnt (show WNT2 Proteins)/GSK3beta/beta-catenin (show CTNNB1 Proteins) signaling pathway and suppressed RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis through NF-kappaB (show NFKB1 Proteins)/c-fos/NFATc1 pathway.
data demonstrate that NC suppressed osteoclastogenesis and prevented OVX-induced bone loss by inhibiting RANKL (show TNFSF11 Proteins)-induced NF-kappaB (show NFKB1 Proteins) and NFATc1 signalling pathways. NC may be a natural and novel treatment for osteoclast-related bone lytic diseases.
A novel role of HPV oncoprotein in facilitating NFAT2 dependent cell proliferation.
There is a correlation between NFATC1 genes and the incidence of congenital heart disease in children, and a correlation between different genotypes and allele frequency and the incidence of the disease.
Increased expression of nuclear factor of activated T cells 1 drives IL-9 (show IL9 Proteins)-mediated allergic asthma.
NFATc1 knockdown strongly reduced the number and the surface area of myotubes, NFATc4 (show NFATC4 Proteins) knockdown increased the surface area of myotubes and reduced the pool of reserve cells.
NFAT2 is an important regulator for the anergic phenotype of chronic lymphocytic leukaemia.
Exposure to UVB radiation induces nuclear translocation and stimulates binding between NFAT5 (show NFAT5 Proteins) and NF-kappaB (show NFKB1 Proteins) proteins in HLE (show ELANE Proteins)-B3 cells. These interactions may form part of the biochemical mechanism of cataractogenesis in UVB-irradiated HLECs.
data identified a novel role of SFKs in preventing aberrant NFAT1 (show NFAT1 Proteins) activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E-04), CADM1 (show CADM1 Proteins) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (show ABCA1 Proteins)-dependent mechanism in which local TNF (show TNF Proteins) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (show TNF Proteins), TNFR1 (show TNFRSF1A Proteins), or TNFR2 (show TNFRSF1B Proteins) serum levels
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac