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regulation of nuclear localization of NFAT (show NFATC1 Proteins) is isoform-specific and dependent on nuclear export processes
Our study demonstrates that Orai1-Ca(2+)-calcineurin-NFATc4 signaling is an essential inflammatory pathway required for TNFalpha-induced endothelial cell activation and vascular inflammation. Therefore, Orai1 may be a potential therapeutic target for treatment of inflammatory diseases.
Both NFATc3 knock-out mice and ILK (show ILK Proteins) conditional-knockdown mice (cKD-ILK (show ILK Proteins)) display symptoms of NDI (polyuria and reduced AQP2 (show AQP2 Proteins) expression).
we found that VIP (show Vip Proteins) inhibits NFAT (show NFATC1 Proteins) nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP (show Vip Proteins) expression could be a protective compensatory mechanism
the transcription factor NFATC3 binds to IRF7 (show IRF7 Proteins) and functions synergistically to enhance IRF7 (show IRF7 Proteins)-mediated IFN expression in Plasmacytoid dendritic cells.
Ca(2 (show CA2 Proteins)+) influx through ASIC1 (show ACCN2 Proteins) mediates chronic hypoxia and ET-1 (show EDN1 Proteins)-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 (show PICK1 Proteins) is necessary for NFATc3 nuclear import.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Study defines the NFAT4/ miR (show MLXIP Proteins)-324-5p/Mtfr1 (show MTFR1 Proteins) axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis.
Disrupting the calcineurin-NFAT (show NFATC1 Proteins) axis by either genetic or pharmacologic approaches confers resistance to the development of social stress-induced voiding and dysfunction.
NFATc3 interacted in a SUMO-dependent manner with Trim17 (show TRIM17 Proteins), an E3 ubiquitin ligase (show MUL1 Proteins) necessary for neuronal apoptosis
A calcineurin- and NFAT-dependent pathway is involved in alpha-synuclein-induced degeneration of midbrain dopaminergic neurons in a Parkinson's disease mouse model.
The NFATc3 first induced the expression of its interaction partner FosB (show FOSB Proteins) before forming the heterodimeric NFATc3-FosB (show FOSB Proteins) transcription factor complex, which bound the proximal AP-1 (show FOSB Proteins) site in the TF gene promoter and activated TF expression.
NFAT1 (show NFAT1 Proteins) is stimulated by subplasmalemmal Ca2 (show CA2 Proteins)+ microdomains, whereas NFAT4 additionally requires Ca2 (show CA2 Proteins)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
Calcineurin together with its upstream molecule, calpain 2 (show CAPN2 Proteins), and its downstream effector, NFAT (show NFATC1 Proteins)-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes.
two NFAT isoforms (NFAT4 and NFAT1) have shifted band-pass windows for the same receptor in the GPCR signaling pathway
Data indicate that RNA interference of NFAT (show NFATC1 Proteins) isoforms NFATc1 (show NFATC1 Proteins), NFATc2 (show NFAT1 Proteins), NFATc3 and NFATc4 (show NFATC4 Proteins) regulate gene expression differentially in human retinal microvascular endothelial cells (HRMEC).
Results show that two protein isoforms NFAT1 (show NFAT1 Proteins) and NFAT4 are both cytosolic and stimulated by the same Ca2 (show CA2 Proteins)+ messenger but require distinct subcellular Ca2 (show CA2 Proteins)+ signals for activity.
Suggest nuclear NF-AT3 (show NFATC4 Proteins) and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 (show TGFB1 Proteins) levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation.
NF-AT affects neural convergent extension.
transcriptional control of morphological and electrophysiological properties of neurons is mediated by distinct NFAT (show NFATC1 Proteins) interactions
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene.
cytoplasmic nuclear factor of activated T-cells 3
, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
, nuclear factor of activated T-cells, cytoplasmic 3
, nuclear factor of activated T-cells, cytoplasmic 3-like
, T-cell transcription factor NFAT4
, T cell transcription factor NFAT4
, nuclear factor of activated T-cells c3 isoform IE-Xa
, nuclear factor of activated T-cell