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Ca(2 (show CA2 Proteins)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins)) c4 axis is required for neuritin (show NRN1 Proteins)-induced Kv4.2 (show KCND2 Proteins) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
Nfatc4 expression was coordinately upregulated by top hypoxia-activated transcription factors, while NFATc4 target genes were enriched in hypoxic neural stem cells.
results indicate that NFAT (show NFATC1 Proteins) is a BACE1 (show BACE Proteins) transcription factor. Our study suggests that inhibition of NFAT (show NFATC1 Proteins)-mediated BACE1 (show BACE Proteins) expression may be a valuable drug target for AD therapy
our results suggest that activation of NHE1 (show SLC9A1 Proteins) induces hypertrophy through the activation of NFAT3/Gata4 (show GATA4 Proteins) and OPN (show SPP1 Proteins) expression
L-carnitine reversed the activation of NFAT3 and PPARa (show PPARA Proteins) caused by carboplatin through altering the phosphorylation of PTEN and AMPK (show PRKAA1 Proteins).
Disrupting the calcineurin-NFAT (show NFATC1 Proteins) axis by either genetic or pharmacologic approaches confers resistance to the development of social stress-induced voiding and dysfunction.
The NFATc4-dependent increase in hippocampal neurogenesis after GABAA (show GABRg1 Proteins) receptor stimulation is required for suppression of anxiety response.
IL-13 (show IL13 Proteins) specifically induced NFAT3 activation through promoting its dephosphorylation in air-liquid interface cultures of tracheal epithelial cells (mTECs).
Data suggest that expression of Itpr1 (inositol 1,4,5-triphosphate receptor 1 (show ITPR1 Proteins)) in cerebral cortex neurons is regulated by dopamine D2 receptors; Itpr1 (show ITPR1 Proteins) is up-regulated via increased binding of NFATc4 and transcription factor AP-1 (show JUN Proteins) to Itpr1 (show ITPR1 Proteins) promoter.
these results reveal a novel PI3K-independent role for p85alpha in controlling VEGF (show VEGFA Proteins) induction during the cellular UVB response by regulating NFAT3 activity.
NFATc1 (show NFATC1 Proteins) knockdown strongly reduced the number and the surface area of myotubes, NFATc4 knockdown increased the surface area of myotubes and reduced the pool of reserve cells.
TBX5 (show TBX5 Proteins) deficiency-mediated downregulation of NFAT3 is crucial for the high cytokine-producing activity of T cells
These results provided evidence supporting the oncogenic potential of NFAT3 and suggested that CDK3 (show CDK3 Proteins)-mediated phosphorylation of NFAT3 has an important role in skin tumorigenesis.
Data indicate that RNA interference of NFAT (show NFATC1 Proteins) isoforms NFATc1 (show NFATC1 Proteins), NFATc2 (show NFAT1 Proteins), NFATc3 (show NFATC3 Proteins) and NFATc4 regulate gene expression differentially in human retinal microvascular endothelial cells (HRMEC).
NFAT3 expression plays a role in regulating CXCR4 (show CXCR4 Proteins) expression.
Suggest nuclear NF-AT3 and NF-AT4 (show NFATC3 Proteins) participates in atrial structural remodeling, and that PICP and TGF-beta1 (show TGFB1 Proteins) levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation.
This is the first study to provide evidence of new and differential roles for NFAT3 and SMAD3 (show SMAD3 Proteins) in the osteoarthritis process in the regulation of miR (show MLXIP Proteins)-140 transcription
Expression level of PPP3R1 (show PPP3R1 Proteins) and GATA4 (show GATA4 Proteins), and NFATC4 genes for transcription factors did not differ in studied subgroups of patients.
Data indicate that NFATc3 (show NFATC3 Proteins) undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min, although NFATc4 remains phosphorylated and localized to the cytosol.
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
cytoplasmic nuclear factor of activated T-cells 4
, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
, nuclear factor of activated T-cells, cytoplasmic 4-like
, T-cell transcription factor NFAT3
, nuclear factor of activated T-cells, cytoplasmic 4
, transcription complex subunit NF-ATc4
, T cell transcription factor NFAT3