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Spreading of PDGFR-alpha-deficient lung fibroblasts was insensitive to increased rigidity, and their migration was not reduced by Rac1-guanine exchange factor (GEF (show ARHGEF2 Proteins))-inhibition. PDGFR-alpha-expressing fibroblasts migrated toward stiffer regions within two-dimensional substrates by increasing migrational persistence (durotaxis).
Histone H3.3K27M and Trp53 (show TP53 Proteins) loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
The diabetes-induced increase in PDGFRalpha+ cells may be mediated by FOXO3 up-regulation via the inhibition of the PI3K/Akt signaling pathway in STZ-induced diabetic mice.
Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT (show AKT1 Proteins) signaling.
OLIG2 (show OLIG2 Proteins) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (show EGFR Proteins)) or platelet-derived growth factor receptor alpha.
Conditional knockout of Pdgfra in Pdgfra-expressing tissues in mouse embryos at different embryonic days (E9.5 and E10.5) resulted in multiple developmental anomalies of the frontonasal region, the cranium and the abdominal wall musculature. Furthermore, the day at which the Pdgfra is deleted influences the repertoire of the anomalies of the conditional knockout embryos.
FOXA3 (show FOXA3 Proteins) is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells.
PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb (show PDGFRB Proteins) in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.
The results from this study indicate that PDGF (show PDGFA Proteins) signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.
transient middle cerebral-arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb (show PDGFRB Proteins)-gene inactivation, including N-PRbeta-KO mice where the Pdgfrb (show PDGFRB Proteins)-gene was mostly inactivated in the brain except that in vascular pericytes
PDGFRalpha activation is an essential component that drives aggressiveness in papillary thyroid carcinoma cells. The signaling pathways are complex, involving not only the MAPK/Erk (show MAPK1 Proteins) but also the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and STAT3 (show STAT3 Proteins) pathways.
Perivascular PDGFR-alpha and -beta were identified as independent markers predicting survival in metastatic colorectal cancer (mCRC).
Data suggest that the platelet derived growth factor receptor alpha (PDGFRalpha)/Stat3 (show STAT3 Proteins) transcription factor/Rb1 (show RB1 Proteins) protein regulatory axis might represent a potential therapeutic target for glioblastoma (GBM) treatment.
Point mutations in the PDGFRa gene, which leads to amino acid residue changes activating the kinase of the receptor, occur in about 5% of Gastrointestinal Stroma Tumors. An activating deletion mutation of the PDGFRA gene has been described in a human Glioblastoma.
FIP1L1 (show FIP1L1 Proteins)/ PDGFRA associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.
Olaratumab had an acceptable adverse event profile in patients with gastrointestinal stromal tumor (GIST). While there was no apparent effect on PFS in patients without PDGFRa mutations, patients with PDGFRalpha-mutant GIST (all with D842V mutations) treated with olaratumab had longer disease control compared with historical data for this genotype
For hot spots in KIT and PDGFRA genes, 23 out of 146 KIT/PDGFRA wild-type cases carried mutations according to next-generation sequencing (NGS).
In vitro activation of PDGFR-alpha leads to translational activation of LAMB1 (show LAMB1 Proteins), which in turn induces an invasive and metastatic phenotype of hepatocellular carcinoma cells exhibiting K19 (show KRT19 Proteins) expression.
PDGFRalpha levels are regulated by SMARCB1 (show SMARCB1 Proteins) expression, and assessment of clinical specimens documents the expression of both PDGFRalpha and FGFR1 (show FGFR1 Proteins) in rhabdoid tumor patients.
The downregulation of platelet-derived growth factor receptor-alpha expression may play a causative role in imatinib-induced thrombocytopenia, a common side effect, in the subset of chronic myeloid leukemia (show BCL11A Proteins) patients with platelet-derived growth factor receptor-alpha +68 GA ins (show INS Proteins)/del, +68 GA del/del, and -909C/A genotypes.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
platelet-derived growth factor receptor, alpha polypeptide
, alpha-type platelet-derived growth factor receptor-like
, Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
, CD140 antigen-like family member A
, PDGF alpha chain
, alpha-type platelet-derived growth factor receptor
, platelet-derived growth factor alpha receptor
, platelet-derived growth factor receptor alpha
, alpha platelet-derived growth factor receptor
, CD140a antigen
, PDGFRA/BCR fusion
, platelet-derived growth factor receptor 2
, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
, tyrosine kinase PDGFR