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By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (show NTRK1 Proteins) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (show NTRK3 Proteins) was faintly detected
BDNF (show BDNF Proteins)-TrkB influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF (show BDNF Proteins)/TrkB2 system in the adult zebrafish retina.
Study showed that complex relationships exist between BDNF (show BDNF Proteins)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
BDNF (show BDNF Proteins)/TrkB axis plays a role in epithelial mesenchymal transition promoting the acquisition of (myo (show SYNPO2 Proteins))fibroblast cell phenotype in idiopathic pulmonary fibrosis.
Low TRKB expression is associated with Parkinson's disease.
Study observed that patients with epilepsy might have a different variant distribution in the NTRK2 gene compared to controls without epilepsy, and that NTRK2 variability might influence age at seizure onset and possibly seizure control.
Study reports that cells residing in the human subependymal zone (SEZ) may maintain their responsiveness to mature BDNF (show BDNF Proteins), although this responsiveness seems to undergo age-related alterations. Results indicate that TrkB-TK+ expression may promote neuronal differentiation, whereas TrkB-TK- expression may block neuronal differentiation in favour of neural precursor proliferation and/or glial differentiation.
these findings demonstrate that TrkB-mediated signaling contributes to the induction of malignant phenotypes (proliferation, invasiveness, angiogenesis, lymphangiogenesis, and tumorigenesis) in gallbladder cancer
our findings suggest that heterodimerization of Her2 (show ERBB2 Proteins) and TrkB receptors gives breast cancer cells a survival advantage in the brain and that dual inhibition of these receptors may hold therapeutic potential
TrkB-containing exosomes play a key role in the control of glioblastoma progression and aggressiveness, as seen in a model of YKL-40 (show CHI3L1 Proteins)-inactivated glioblastoma cells
Female sex and specific allelic variations in the NTRK2 gene were independently associated with mood disorders or depressive disorders in temporal lobe epilepsy patients.
Report an association between antidepressant worsening suicidal ideation and SNP rs1439050 of NTRK2 in depressed subjects treated by tianeptine.
This work demonstrates that DHF, through activation of TrkB signaling pathway, has a preventive function in d-glucose-induced apoptosis in PRE cells in diabetic retinopathy.
increased BDNF (show BDNF Proteins)-TrkB signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR (show CHRNA7 Proteins) plays a key role in depression
The changes in the expression patterns of proBDNF, BDNF (show BDNF Proteins), and their receptors under the influence of chronic alcohol consumption in the depressive ASC (show STS Proteins) strain and nondepressive CBA strain mice are different.
A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor (show BDNF Proteins)/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life.
Imipramine protected bupivacaine-induced neurotoxicity in DRG, likely via the co-activation of TrkA (show NTRK1 Proteins) and TrkB signaling pathways.
Ventral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavior otherwise facilitated by developmental stress hormone exposure.
BDNF (show BDNF Proteins) acts retrogradely on TrkB in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week.
The three receptor sets considered (mAChR (show CHRM3 Proteins), AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons
findings show that BDNF (show BDNF Proteins)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (show SREBF2 Proteins). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (show BDNF Proteins)-TrkB signaling as a pathologic mechanism during periods of chronic stress.
inhibition of Sig (show PICALM Proteins)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF (show BDNF Proteins)) and its receptor (BDNF (show BDNF Proteins) receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (show BDNF Proteins)-Trk-B
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
neurotrophin receptor B xTrkB-alpha
, BDNF/NT-3 growth factors receptor
, neurotrophic tyrosine kinase, receptor, type 2
, BDNF/NT-3 growth factors receptor-like
, neurotrophic tyrosine kinase receptor type 2
, trkB tyrosine kinase
, tyrosine kinase receptor
, BDNF-tropomyosine receptor kinase B
, tropomyosin-related kinase B
, tyrosine kinase receptor B
, neural receptor protein-tyrosine kinase (trkB)
, trkB protein