No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC was faintly detected
BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.
Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
coexpression of BDNF and TrkB is associated with poor prognosis in small cell lung cancer patients
NTRK2 gene fusion occurs in primary and metastatic melanomas.
A cross-sectional study was performed in which the expression of TrkA, TrkB, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) was analyzed by immunohistochemistry of 154 melanoma samples. We investigated NT/TRK expression associations with prognostic factors for melanoma, relapse-free survival (RFS), and overall survival (OS).
Intracellular processing and efficacy was shown in HEK293 cells and SH-SY5Y neuroblastoma cells using plasmid DNA and after incorporating the TrkB-2A-mBDNF into an AAV2 vector. Increased BDNF/TrkB-mediated intracellular signaling pathways were observed after AAV2 vector transfection while increased TrkB phosphorylation could be detected in combination with neuroprotection from hydrogen peroxide-induced oxidative stress.
Trk receptors Trk-A, Trk-B, and Trk-C have a propensity to interact laterally and to form dimers even in the absence of ligand.
Data suggest that in both head and neck squamous cell carcinoma (HNSCC) cell lines and tissues, the high positive TrkB+ reaction, which was detected in 20% of all cases, is a result of an up-regulation of normally arranged wild-type gene, and not a result of a rearrangement.
rs2289656 genetic polymorphism is associated with acute suicide attempts in depressed patients
High TRKB expression is associated with B-cell chronic lymphocytic leukemia.
recurrent gene fusions in RAF1, BRAF, and NTRK1/2 kinases suggest a distinct molecular tumor subtype with consistent S100 and CD34 immunoreactivity
MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM.
TRKB role in epithelial-mesenchymal transition, migration and invasion of cervical cancer.
BDNF/TrkB axis plays a role in epithelial mesenchymal transition promoting the acquisition of (myo)fibroblast cell phenotype in idiopathic pulmonary fibrosis.
Low TRKB expression is associated with Parkinson's disease.
Study observed that patients with epilepsy might have a different variant distribution in the NTRK2 gene compared to controls without epilepsy, and that NTRK2 variability might influence age at seizure onset and possibly seizure control.
Study reports that cells residing in the human subependymal zone (SEZ) may maintain their responsiveness to mature BDNF, although this responsiveness seems to undergo age-related alterations. Results indicate that TrkB-TK+ expression may promote neuronal differentiation, whereas TrkB-TK- expression may block neuronal differentiation in favour of neural precursor proliferation and/or glial differentiation.
these findings demonstrate that TrkB-mediated signaling contributes to the induction of malignant phenotypes (proliferation, invasiveness, angiogenesis, lymphangiogenesis, and tumorigenesis) in gallbladder cancer
our findings suggest that heterodimerization of Her2 and TrkB receptors gives breast cancer cells a survival advantage in the brain and that dual inhibition of these receptors may hold therapeutic potential
TrkB-containing exosomes play a key role in the control of glioblastoma progression and aggressiveness, as seen in a model of YKL-40-inactivated glioblastoma cells
Female sex and specific allelic variations in the NTRK2 gene were independently associated with mood disorders or depressive disorders in temporal lobe epilepsy patients.
Report an association between antidepressant worsening suicidal ideation and SNP rs1439050 of NTRK2 in depressed subjects treated by tianeptine.
corticostriatal TrkB-mediated plasticity appears necessary for balancing actions and habits.
our data suggest a novel role for SOCS2 in interacting with and regulating the trafficking of TrkB, leading to increased neurite outgrowth in hippocampus neurons.
Compared with trkB.T1 wild type (WT) mice, the differentially expressed genes (DEGs) in trkB.T1 KO mice following spinal cord injury at different time points were screened out. The significant DEGs were subjected to function, coexpression and proteinprotein interaction (PPI) network analyses. Construction of a Venn diagram revealed the overlap of several DEGs in trkB.T1 KO mice under different conditions.
Study demonstrates that isoflurane dose-dependently regulates TrkB and GSK3beta phosphorylation in the adult rodent brain and most prominent changes are observed when burst-suppression pattern in the EEG emerge.
BDNF, signaling through TrkB receptors on cortistatin-expressing cells, promotes excitatory drive onto these cells. Loss of excitatory drive onto CST-expressing cells that lack TrkB receptors may contribute to observed hyperexcitability and epileptogenesis.
our data show that DMH(TrkB) neurons are a population of neurons that are necessary and sufficient to suppress appetite and maintain physiological satiation. Pharmacological activation of these neurons could be a therapeutic intervention for the treatment of obesity.
TrkB expression and dependence divides gustatory neurons into three subpopulations: 1) neurons that always express TrkB and are TrkB-dependent during development (50%), 2) neurons dependent on TrkB during development but that downregulate TrkB expression between E15.5 and E17.5 (41%), and 3) neurons that never express or depend on TrkB (9%).
Prep1 deficiency alters olfactory morpho-functional integrity and olfaction-mediated eating behavior by affecting BDNF-TrkB signaling.
TrkB uncouples RasGrf1 from NR2B and facilitates a decrease in NMDA signaling associated with LTD.
An acute bout of exercise can recover BDNF-TrkB signalling in the prefrontal cortex of obese, glucose intolerant mice.
Results give strong evidence for a cell type-specific brain derived neurotrophin factor (BDNF), TrkB signaling in modulating neuronal architecture. Study propose that a BDNF-independent transactivation of TrkB receptor may be able to compensate the lack of BDNF signaling to modulate neuronal morphology in a cell type-specific manner.
Deletion of T1 isoform restores the number of PA-positive neurons and physiological levels of long term potentiation in pre-symptomatic ALS SOD1 mice.
Low TRKB Expression is associated with social dominance.
We report here on the incorporation of a BDNF mimetic sequence into a supramolecular peptide amphiphile filamentous nanostructure capable of activating the BDNF receptor TrkB and downstream signaling in primary cortical neurons in vitro.
Data suggest that neurotrophic tyrosine receptor kinase type 2 (TrkB)-dependent neuronal differentiation is involved in the sustained antidepressant effects of ketamine.
increased BDNF-TrkB signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR plays a key role in depression
The changes in the expression patterns of proBDNF, BDNF, and their receptors under the influence of chronic alcohol consumption in the depressive ASC strain and nondepressive CBA strain mice are different.
A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life.
Imipramine protected bupivacaine-induced neurotoxicity in DRG, likely via the co-activation of TrkA and TrkB signaling pathways.
Ventral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavior otherwise facilitated by developmental stress hormone exposure.
Furthermore, we found potential selection signatures including LRP1B and NTRK2 genes that might be implicated with meat and reproductive traits in cattle. In this study, the results showed that both Hanwoo and Chikso populations were not under severe level of inbreeding.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf-Trk-B
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
neurotrophin receptor B xTrkB-alpha
, BDNF/NT-3 growth factors receptor
, neurotrophic tyrosine kinase, receptor, type 2
, BDNF/NT-3 growth factors receptor-like
, neurotrophic tyrosine kinase receptor type 2
, trkB tyrosine kinase
, tyrosine kinase receptor
, BDNF-tropomyosine receptor kinase B
, tropomyosin-related kinase B
, tyrosine kinase receptor B
, neural receptor protein-tyrosine kinase (trkB)
, trkB protein