Browse our WASF1 Proteins (WASF1)

Xenopus laevis WAS Protein Family, Member 1 (WASF1) interaction partners

1. Lpd regulates mesenchymal neural crest cell migration cell autonomously in Xenopus laevis via the Scar/WAVE complex.

2. this sudy identifies Wave1 as a maternal reprogramming factor that also has a necessary role in gene activation in development.

Arabidopsis thaliana WAS Protein Family, Member 1 (WASF1) interaction partners

1. The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex. Light is essential for stabilizing the SCAR complex in the plasma membrane, which is necessary for maintaining longitudinally organized F-actin to sustain rapid root growth.

Human WAS Protein Family, Member 1 (WASF1) interaction partners

1. Results from a study on gene expression variability markers in early-stage human embryos shows that WASF1 is a putative expression variability marker for the 3-day, 8-cell embryo stage.

2. WASP and SCAR drive pseudopod formation and are conserved in actin-filled pseudopod-based motility.

3. Results suggested that WAVE1 is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the Beclin1/Bcl-2 and Beclin1/PI3K- complex-dependent pathways.

4. Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex.

5. we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients

6. a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration

7. A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta production

8. D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation.

9. WAVE1 has unique activities independent of Arp2/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain.

10. The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.

11. WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K/AKT and p38MAPK signaling pathways in epithelial ovarian cancer.

12. Scar/WAVE regulatory complex and N-WASP play opposing roles in 3D epithelial cell migration

13. mRNAs encoding structural and regulatory components of the WAVE complex are localized to the leading edge of the cell, suggesting that localized protein synthesis plays a pivotal role in controlling cell spreading and migration.

14. Study finds that WAVE1 overexpression is associated with an unfavorable prognosis. WAVE1 is an independent prognostic factor for EOC, which suggests that it is a novel and crucial predictor for EOC metastasis.

15. mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia.

16. Arf GTPases may be central components in WAVE signalling, acting directly, alongside Rac1.

17. WAVE1 might be involved in the migration and invasion of K562 cells through regulation of the expression level of MMP-2.

18. Higher levels of WAVE1 in the bone marrow indicate an unfavorable prognosis in children with AML.

19. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

20. CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.

Cow (Bovine) WAS Protein Family, Member 1 (WASF1) interaction partners

1. Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores.