Browse our WASF1 Proteins (WASF1)

Xenopus laevis WAS Protein Family, Member 1 (WASF1) interaction partners

1. Lpd (show ACSBG1 Proteins) regulates mesenchymal neu (show AKT1 Proteins)ral crest cell migration cell autonomously in Xeno (show ACSBG1 Proteins)pus laevis via the Scar/WAVE complex.

2. this sudy identifies Wave1 as a maternal reprogramming factor that also has a necessary role in gene activation in development.

Arabidopsis thaliana WAS Protein Family, Member 1 (WASF1) interaction partners

1. The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex. Light is essential for stabilizing the SCAR complex in the plasma membrane, which is necessary for maintaining longitudinally organized F-actin to sustain rapid root growth.

Human WAS Protein Family, Member 1 (WASF1) interaction partners

1. WASP and SCAR drive pseudopod formation and are conserved in actin-filled pseudopod-based motility.

2. Results suggested that WAVE1 is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the Beclin1 (show BECN1 Proteins)/Bcl-2 (show BCL2 Proteins) and Beclin1 (show BECN1 Proteins)/PI3K (show PIK3CA Proteins)- complex-dependent pathways.

3. Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 (show PCSK1 Proteins) cells through their interaction with the ARP2 (show ACTR2 Proteins)/3 complex.

4. we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients

5. a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration

6. A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta (show APP Proteins) production

7. D620N mutation in VPS35 (show vps35 Proteins) restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation.

8. WAVE1 has unique activities independent of Arp2 (show ACTR2 Proteins)/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain.

9. The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.

10. WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and p38MAPK (show MAPK14 Proteins) signaling pathways in epithelial ovarian cancer.

Mouse (Murine) WAS Protein Family, Member 1 (WASF1) interaction partners

1. We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl (show ABL1 Proteins)-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP (show VASP Proteins), whereas Src (show SRC Proteins)-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP (show VASP Proteins)

2. WAVE1 phosphorylation in podocytes. Synaptopodin (show SYNPO Proteins) is a well-characterized target of CsA (show HSPA9 Proteins). WAVE1 overexpression and synaptopodin (show SYNPO Proteins) knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin (show SYNPO Proteins) expression, and vice versa

3. Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.

4. Lpd (show ACSBG1 Proteins) directly binds active Rac (show AKT1 Proteins), which regulates a direct interaction between Lpd (show ACSBG1 Proteins) and the Scar/WAVE complex

5. An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.

6. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

7. In cell migration WAVE1 is essential in MMP-dependent migration in extracellular matrix and WAVE2 (show WASF2 Proteins) is for leading edge extension for directed migration in general.

8. Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.

9. data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology

10. NESH (Abi-3 (show ABI3 Proteins)), like Abi-1 (show ABI1 Proteins) and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (show ABL1 Proteins).

Cow (Bovine) WAS Protein Family, Member 1 (WASF1) interaction partners

1. Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores.