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Study demonstrated that the expression levels of WAVE3 in pancreatic cancer tissues were prominently higher than those in the non-cancerous tissues which seems to be associated with lymphatic metastasis, poorly differentiated tumors. Furthermore, findings suggest that WAVE3 influences cell proliferation, migration and invasion via the AKT pathway.
Results suggest that Wiskott-Aldrich syndrome verprolin-homologous protein 3 (WAVE3) may be pivotal in ovarian cancer cell motility, invasion and oncogenesis.
p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion
we show that WASF3 is present in the HER2 immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 expression.The engagement of WASF3 with the HER2/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2/HER3 activation of JAK/STAT signaling.
we show that stapled peptides targeting the interface between NCKAP1 and CYFIP1 destabilize the WASF3 complex... thereby suppressing invasion and metastasis of breast cancer cells.
It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC.
studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB is required for invadopodia formation as well as MMP9 expression and activity that are needed for cancer cells to degrade the ECM
WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells.
WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail.
miR-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3.
Upregulated WAVE3 expression is essential for TGF-beta-mediated EMT and metastasis of triple-negative breast cancer cells.
ZEB1/2 upregulation by WASF3 results from downregulation of KISS1, leading to the release of inhibition of nuclear factor (NF)kappaB by IkappaBalpha
these results define a novel signaling network whereby JAK2/STAT3 signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility.
MMP-9 and WAVE3 were over-expressed in colorectal cancer tissues compared with normal mucosa.
demonstrate WASF3 is a HIF1A-regulated gene and suggests a mechanism to explain the observation of elevated expression of WASF3 in advanced stage tumors
increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer
WAVE3-depleted breast cancer cells move more slowly but more persistently on a 2-dimensional matrix. They typically only show one lamellipod. WAVE3 appears to have no role in driving invasiveness. Lamellipodial persistence is not crucial in 3-dimensions.
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3