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Results suggest that Wiskott-Aldrich syndrome verprolin-homologous protein 3 (show HSPB3 Antibodies) (WAVE3) may be pivotal in ovarian cancer cell motility, invasion and oncogenesis.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 Antibodies) expression via E2F1 transcription factor (show E2F1 Antibodies) 1 (show HNF1A Antibodies), promoting Wasf3/Wave3/MMP9 (show MMP9 Antibodies) signaling and bladder cancer invasion
we show that WASF3 is present in the HER2 (show ERBB2 Antibodies) immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 (show ERBB2 Antibodies) expression.The engagement of WASF3 with the HER2 (show ERBB2 Antibodies)/HER3 (show ERBB3 Antibodies) complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (show ERBB2 Antibodies)/HER3 (show ERBB3 Antibodies) activation of JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling.
we show that stapled peptides targeting the interface between NCKAP1 (show NCKAP1 Antibodies) and CYFIP1 (show CYFIP1 Antibodies) destabilize the WASF3 complex... thereby suppressing invasion and metastasis of breast cancer cells.
It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC.
studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 (show WASF1 Antibodies) and -3 to the metastatic phenotype of PC-3 (show PCSK1 Antibodies) cells through their interaction with the ARP2 (show ACTR2 Antibodies)/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A (show ATAD3A Antibodies) and GRP78 (show HSPA5 Antibodies), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB (show NFKB1 Antibodies) is required for invadopodia formation as well as MMP9 (show MMP9 Antibodies) expression and activity that are needed for cancer cells to degrade the ECM (show MMRN1 Antibodies)
WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells.
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3