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we provide supportive evidence that genetic variants at FOXP1, BARX1, and FOXF1 confer risk for the development of EAC.
PITX2, BARX1, and FOXC1 mutations were absent in De Hauwere syndrome and suggest that De Hauwere syndrome is caused by a different gene.
Regional expression of barx1 was observed in epithelium before mixed dentition, while during mixed dentition gene appeared in hyaline cartilage. Expression of barx1 appears in cleft lip palate affected structures mainly in mixed dentition.
barx1 represses joints and promotes cartilage in the craniofacial skeleton.
These results indicate an essential role for barx1 at early stages of chondrogenesis within the developing zebrafish viscerocranium.
BARX1 functions in intestinal rotation and stomach myogenesis occur through this small group of intermediary transcription factors.
Barx1 control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt pathway activity
miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1.
Data show that Barx1 antagonizes Wnt signaling, and Barx1 loss in the mesenchyme prevents stomach epithelial differentiation of overlying endoderm and induces intestine-specific genes instead.
Results describe the independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.
Hoxa2 also repressed the expression of its downstream targets Barx1 within the palate.
This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia.
BarH-like homeobox 1
, homeobox protein BarH-like 1
, barH-class homeodomain transcription factor 4
, bar class homeoprotein Barx1b
, homeobox protein BarH-like 1b
, BARX homeobox 1
, Bar homeobox protein 2