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anti-Human COL11A1 Antibodies:
anti-Mouse (Murine) COL11A1 Antibodies:
anti-Rat (Rattus) COL11A1 Antibodies:
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Mouse (Murine) Polyclonal COL11A1 Primary Antibody for WB - ABIN4895101
Seet, Toh, Chu, Finger, Chua, Wong: Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis. in Disease models & mechanisms 2017
These results showed that the frequency distribution of genotypes of the rs2229783 polymorphism in COL11A1 was significantly different between the Kashin-Beck Disease (KBD) and control groups; the expression level of COL11A in cartilage was significantly lower in the KBD group, but no association was found between the rs2229783 and the severity of KBD.
We confirmed that the rs1676486 of COL11A may be functionally associated with lumbar disc herniation (LDH) in the Chinese population. Extracellular matrix related proteins may play an important role in the pathogenesis of LDH. Our findings shed light on a better understanding of the pathogenesis of LDH, which could be a promising target for a novel treatment modality of LDH.
Study found one gene significantly associated when looking for associations between multiple common and rare variants with pneumococcal meningitis susceptibility, namely the COL11A1 gene.
The SNPs rs1337185 in COL11A1 and rs162509 in ADAMTS5 (show ADAMTS5 Antibodies) are associated with susceptibility to lumbar disc degeneration. The C allele of rs1337185 is risky for patients who are affected by lumbar pathologies such as disc herniation, stenosis and spondylolisthesis. The G allele of rs16250 represents a risk factor for the development of disc herniation.
In this study, three novel and two known mutations in the COL2A1 (show COL2A1 Antibodies) gene were identified in six of 16 Chinese patients with Stickler syndrome. This is the first study in a cohort of Chinese patients with Stickler syndrome, and the results expand the mutation spectrum of the COL2A1 (show COL2A1 Antibodies) gene.
Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
genetic variants of COL11A1 contribute to adult height in Chinese Han population but not to children height
proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine (show SPARC Antibodies), and periostin (show POSTN Antibodies) expression was significantly increased in the intratumoral stroma of pancreatic ductal adenocarcinomas compared to paired non-neoplastic pancreata
we demonstrate how COL11A1 regulates twist family basic helix-loop-helix transcription factor (show HEY1 Antibodies) 1 (show HNF1A Antibodies)-related protein 1 (TWIST1 (show TWIST1 Antibodies)) to induce chemoresistance and inhibit apoptosis in ovarian cancer cells
the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer
Taken together, these results indicate that the transcription factor Sp1 (show SP1 Antibodies) upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.
these results indicate that the transcription factor NF-Y regulates the proximal promoter activity of mouse Col11a1 gene in chondrocytes
Stickler syndrome and Marshall syndrome mutations in COL11A1 cause hearing loss via dominant negative effects upon wild-type fibrillar collagen polypeptides in the extracellular matrices of the cochlea.
the cho mutation leads to osteoarthritis through a mechanism that does not initially involve mechanical factors.
The expression patterns suggest essential roles for Col11a1 and Col11a2 (show COL11A2 Antibodies) in the basilar or tectorial membranes.
Lef1 (show LEF1 Antibodies) is an activator of the Col11a1 promoter and that Col11a1 suppresses terminal osteoblast differentiation
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene.
alpha 1 type XI collagen
, collagen alpha-1(XI) chain
, collagen type XI alpha-1a
, collagen alpha-3(V) chain
, collagen, type XI, alpha 1
, collagen alpha-1(XI) chain-like
, collagen XI, alpha-1 polypeptide
, a1(XI) collagen
, pro-alpha1(XI) collagen
, procollagen, type XI, alpha 1
, collagen type XI
, collagen type a1(XI)6A-7-8
, collagen type a1(XI)6B-7
, procollagen type XI alpha 1