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Data show that thymidine phosphorylase (TYMP) positive patients had higher systemic immune-inflammation index (SII (show TCEA1 Proteins)) score.
Investigated the contribution of myeloma-expressed thymidine phosphorylase (TP) to bone lesions. In osteoblast progenitors, TP up-regulated the methylation of RUNX2 (show RUNX2 Proteins) and osterix (show SP7 Proteins), leading to decreased bone formation. In osteoclast progenitors, TP up-regulated the methylation of IRF8 (show IRF8 Proteins), leading to increased bone resorption.
TP(thymidine phosphorylase ) curbed the expression of three proteins-IRF8 (show IRF8 Proteins), RUNX2 (show RUNX2 Proteins), and osterix (show SP7 Proteins). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling and increased the methyltransferase DNMT3A's expression
TP expression is associated with tumor stage, histological grade and thrombocytosis in patients with renal cell carcinoma (show MOK Proteins)
Studied the role of thymidine phosphorylase (TP) in promoting the invasion and metastasis of hepatocellular carcinoma (HCC (show FAM126A Proteins)). It was shown that TP correlated with MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) expression, and that TP mediated the migration of tumor cells through activity of MMPs in HCC (show FAM126A Proteins) cell lines.
Increases in gene expression levels of TYMP, DPYD (show DPYD Proteins), and HIF1A (show HIF1A Proteins) in tumor tissues at 7 days after the start of CRT (show SLC6A8 Proteins) may be useful for predicting the efficacy of CRT (show SLC6A8 Proteins) including S-1 or UFT
the highest expression of GGH (show GGH Proteins) and EGFR (show EGFR Proteins) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Proteins), FPGS (show FPGS Proteins), TOP1 (show TOP1 Proteins) and ERCC1 (show ERCC1 Proteins) was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum
High VEGF (show VEGFA Proteins) expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34 (show CD34 Proteins)
Pretreatment expression of thymidine phosphorylase/HIF-1alpha (show HIF1A Proteins) were found to predict pathologic response and outcomes in clinical stage II/III rectal cancer receiving neoadjuvant chemoradiotherapy.
Gastrointestinal cancer patient carriers of the thymidine phosphorylase rs11479 T allele, with a low platelet count, could be at risk of a poor outcome.
data identify TYMP as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA (show VEGFA Proteins) together promote blood-brain barrier breakdown.
TYMP participates in multiple platelet signaling pathways and regulates platelet activation and thrombosis. Targeting TYMP might be a novel antiplatelet and antithrombosis therapy.
Thymidine phosphorylase and UPP1 (show UPP1 Proteins) double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified.
, endothelial cell growth factor 1 (platelet-derived)
, platelet derived growth factor, endothelial cell
, thymidine phosphorylase
, Thymidine phosphorylase