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CD36 is a major mediator of FA-induced release of CCK and secretin. These peptides contribute to the role of CD36 in fat absorption and to its pleiotropic metabolic effects.
Data suggest that the interaction between secretin peptide residue H1 and secretin receptor residue W274 is most compatible with a hydrophobic interaction.
a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin
Secretin effect on increase in transcription of the tyrosine hydroxylase (Th) gene and modulate catecholamine secretion, was tested.
binding and activity of a series of 11 truncated and lactam-constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor
secretin significantly inhibited the tumor size and more than doubled tumor latency, which was associated with a decrease in proliferating cell nuclear antigen and an increase in cleaved-caspase 3 expression levels
The purpose of this study was to investigate whether secretin exhibits similar properties in vitro by forming micelles in aqueous solution and interacting with phospholipids
Human VPAC1 receptor selectivity filter; Identification of a critical domain for restricting binding
fine structure in 11p15.5 and sequence variation in patients with autism
human secretin gene is controlled by the Sp1/Sp3 transcription factors ratio and the methylation status of the promoter
Transgenic mouse study suggests a trophic role for secretin on neurons known to be involved in multiple superior functions in the normal brain, and lost in neurodegenerative disorders.
Secretin mRNAs are found in Purkinje cells and secretin-immunoreactivities are localized in both the soma and dendrites of Purkinje cells of human cerebellum.
small heterodimer partner and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway
first pathway is by changing the expression levels of nuclear factor-I C(NFI-C) and secretin proteins while the second pathway is by modifying the phosphorylation status of both NFI-C and secretin proteins via cyclin-dependent kinase 1
Peptic ulceration may be a hormonal (secfretin) deficiency disease.
These results collectively suggest that variable of tandem repeats could potentially be a functional regulator to control the expression of the human secretin gene in different individuals.
secretin acts through stimulation of presynaptic cholinergic neurons in a vagally mediated pathway.
Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).
synthetic porcine and human forms of secretin are equivalent to one another and to biologic porcine secretin and can be used interchangeably in pancreatic function testing
The increased calcium response mediated by secretin in the absence of GLP-1R was paralleled by an increased glucose-dependent insulin response, indicating that the heterodimeric receptor complexes modulate secretin responses.
Study demonstrates that secretin-induced dendritic oxytocin release from supraoptic neurons enhances social recognition. The newly defined secretin-oxytocin system may lead to a possible treatment for social deficits.
Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization.
Results suggest a role in motor coordination and motor learning for SCT expressed in cerebellar Purkinje cells
a novel positive feedback pathway involving secretin and CD36 to enhance intestinal lipid absorption is being proposed.
in vitro lipolytic effects of Sct
The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy.
secretin is not required for normal pancreatic development or adaptive growth mediated by CCK.
Immunohistochemical staining of the arcuate nucleus shows colocalization of Sct receptors with proopiomelanocortin that provide anatomical evidence for a possible anorectic role of Sct.
Findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body.
Secretin expression is present in several developing brain regions such as cephalic mesenchyme, cerebellar primordium & choroid plexus as well as epithelial villi lining & inner circular muscle of developing intestine in mouse embryos.
These findings suggest that secretin is involved in synaptic function in the adult brain.
results suggest that secretin signal plays a neuroprotective role of neuronal progenitor cells against the neurotoxicity of ethanol
Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion.
, secretin precursor variant 1