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our findings demonstrate that 5-hmC loss is an epigenetic hallmark of hepatocellular carcinoma , and miR (show MLXIP Proteins)-29a is an important epigenetic modifier, promoting HCC (show FAM126A Proteins) metastasis through TET-SOCS1 (show SOCS1 Proteins)-MMP9 (show MMP9 Proteins) axis silencing. The results offer a new strategy for epigenetic cancer therapy
These results suggest that TET1 potentially promotes the cytodifferentiation potential of human dental pulp cells through its DNA demethylation machinery and upregulation of FAM20C (show FAM20C Proteins) protein expression.
a mechanism how L1 elements get activated in the absence of Mecp2
Data show that ten-eleven translocation 1 (TET1) suppresses tumor cell growth, migration and invasion through demethylation of CpG island in PTEN promoter by increasing 5-hmC content.
Therefore, chemical hypoxia not only causes overexpression of TET1 and TET2 but also could gradually do promoter demethylation of same genes
Overexpression of the wild-type TET1/2/3 3'UTR caused a significant increase in EZH2 (show EZH2 Proteins) expression and tumor growth, whereas the mutation in miR (show MLXIP Proteins)-26-binding sites abolished this effect.
Data show that low TET1 mRNA levels were significantly associated with worse metastases-free survival.
TET1 binds to tumor suppressor promoters and induces their re-expression through active DNA demethylation.
Loss of TET1 expression facilitates colon cancer cell migration via H3K27me3-mediated repression of E-cadherin (show CDH1 Proteins) expression.
TET1 potently inhibited canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (show SFRP2 Proteins) and DKK1 (show DKK1 Proteins), which was associated with inhibition of EMT (show ITK Proteins) and cancer cell metastasis.
Tet1/2/3 proteins have a key role in modulating Wnt (show WNT2 Proteins) signaling and establishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and embryonic stem cells
TET1 and TET2 play an important role in the proliferation of neural stem cells in the adult mouse brain.
findings reveal a novel role for TET1, an enzyme important for DNA hydroxymethylation, in the brain's reward circuitry in modulating stress responses in mice. Also identify a subset of genes that are regulated by TET1 in this circuitry.
These findings suggest that the catalytic and scaffolding activities of TDG (show TDG Proteins) are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG (show TDG Proteins) complexes.
these results indicate that miR (show MLXIP Proteins)-29 is a direct regulator of Tet1 in mouse ESCs (show NR2E3 Proteins)
Nanog (show NANOG Proteins), Oct4 (show POU5F1 Proteins) and Tet1 interplay in establishing stem cell pluripotency has been described.
that Tet1 modulates HIF-2alpha (show EPAS1 Proteins) and HIF-1alpha (show HIF1A Proteins) through different mechanisms.
TET1 is an epigenetic determinant for regulating genes that are crucial to closure of the anterior neural tube.
MBD1 (show DPEP1 Proteins) regulates localization and activity of Tet1 in a CXXC3 (show MBD1 Proteins) domain-dependent manner.
TET3 dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Proteins).
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
CXXC finger 6
, CXXC zinc finger 6
, CXXC-type zinc finger protein 6
, leukemia-associated protein with a CXXC domain
, methylcytosine dioxygenase TET1
, ten-eleven translocation 1 gene protein
, ten-eleven translocation-1
, tet oncogene 1
, ten-eleven translocation 1 gene protein homolog
, tet methylcytosine dioxygenase 1