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high activity UGT1A7 genotype is associated with an increased risk for Warthin's tumor.
Increased UGT1A7 expression is associated with pancreatic cancer.
The rate of Results show that UGT1A7*12 allele frequency was not significantly different between the Uzbek and Japanese populations.
The presence of UGT1A1*28, UGT1A7*3, UGT1A9*22 genotypes decreases SN-38 clearance between 20 and 36%
Results suggest that CYP3A4 changes the catalytic function of the UGT1A subfamily in a UGT isoform-specific manner.
Polymorphism in UDP-glucuronosyltransferase 1A7 is associated with colorectal cancer.
the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma (Meta-Analysis)
there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.
UGT1A7 variants play a relevant role for pancreas diseases
7-fold increased risk of cancer was observed in smokers with UGT1A7 low activity genotypes. UGT1A7 haplotype carrying C allele (T622C) showed 10-fold increased risk of cancer.
UGT1A7 heterozygosity predicted lower mycophenolic acid (MPA) trough concentrations.
In a study of Japanese renal transplant recipients, there are no significant differences in the area under the plasma concentration-time curve ratio of mycophenolic acid (MPA) glucuronide/MPA between UGT1A7 I399C/T genotypes.
The results also indicated that UGT1A1, UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2B7 are the most important six UGT isoforms for metabolizing the three dihydroxyflavones and seven monohydroxyflavones.
The genetic polymorphisms of UGT1A7 are associated with the susceptibility of bladder cancer and have interactions with smoking in bladder carcinogenesis.
Data identified nine different genotypes in UGT1A7, demonstrating a high variability of alleles and haplotypes, which have important roles in modifying expression and activity of UGTs.
Frequent haplotypes containing several UGT1 allelic variants should be taken into account in studies on the association between diseases, abnormal drug reactions, and UGT1 family polymorphisms.
UGT1A7 polymorphisms together with IL-1 beta have a role in hepatocellular carcinoma in Japanese Hepatitic C virus-infected patients
Genetic polymorphisms in UGT1A7 is associated with colorectal cancer
the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese
carriage of the UGT1A7*3 allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with colorectal cancer patients
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
UDP glycosyltransferase 1 family, polypeptide A7
, UDP-glucuronosyltransferase 1 family polypeptide A7s
, UDP-glucuronosyltransferase 1-7
, UDP-glucuronosyltransferase 1-G
, UDP-glucuronosyltransferase 1A7
, UDP glucuronosyltransferase 1 family, polypeptide A10
, UDP glucuronosyltransferase 1 family, polypeptide A6
, UDP glucuronosyltransferase 1 family, polypeptide A7
, UDP glucuronosyltransferase 1 family, polypeptide A8
, UDP glucuronosyltransferase 1 family, polypeptide A9
, UDP glycosyltransferase 1 family, polypeptide A6
, UDP glycosyl transferase 1A7
, UDP glucuronosyltransferase 1 family polypeptide a7 short isoform