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high activity UGT1A7 genotype is associated with an increased risk for Warthin's tumor.
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Increased UGT1A7 expression is associated with pancreatic cancer.
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The rate of Results show that UGT1A7*12 allele frequency was not significantly different between the Uzbek and Japanese populations.
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The presence of UGT1A1*28, UGT1A7*3, UGT1A9*22 genotypes decreases SN-38 clearance between 20 and 36%
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Results suggest that CYP3A4 changes the catalytic function of the UGT1A subfamily in a UGT isoform-specific manner.
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Polymorphism in UDP-glucuronosyltransferase 1A7 is associated with colorectal cancer.
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the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma (Meta-Analysis)
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there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.
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UGT1A7 variants play a relevant role for pancreas diseases
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7-fold increased risk of cancer was observed in smokers with UGT1A7 low activity genotypes. UGT1A7 haplotype carrying C allele (T622C) showed 10-fold increased risk of cancer.
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UGT1A7 heterozygosity predicted lower mycophenolic acid (MPA) trough concentrations.
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In a study of Japanese renal transplant recipients, there are no significant differences in the area under the plasma concentration-time curve ratio of mycophenolic acid (MPA) glucuronide/MPA between UGT1A7 I399C/T genotypes.
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The results also indicated that UGT1A1, UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2B7 are the most important six UGT isoforms for metabolizing the three dihydroxyflavones and seven monohydroxyflavones.
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The genetic polymorphisms of UGT1A7 are associated with the susceptibility of bladder cancer and have interactions with smoking in bladder carcinogenesis.
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Data identified nine different genotypes in UGT1A7, demonstrating a high variability of alleles and haplotypes, which have important roles in modifying expression and activity of UGTs.
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Frequent haplotypes containing several UGT1 allelic variants should be taken into account in studies on the association between diseases, abnormal drug reactions, and UGT1 family polymorphisms.
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UGT1A7 polymorphisms together with IL-1 beta have a role in hepatocellular carcinoma in Japanese Hepatitic C virus-infected patients
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Genetic polymorphisms in UGT1A7 is associated with colorectal cancer
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the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese
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carriage of the UGT1A7*3 allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with colorectal cancer patients
