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Increased UGT1A7 expression is associated with pancreatic cancer.
The rate of Results show that UGT1A7*12 allele frequency was not significantly different between the Uzbek and Japanese populations.
The presence of UGT1A1 (show UGT1A1 Antibodies)*28, UGT1A7*3, UGT1A9 (show UGT1A9 Antibodies)*22 genotypes decreases SN-38 clearance between 20 and 36%
Results suggest that CYP3A4 (show CYP3A4 Antibodies) changes the catalytic function of the UGT1A (show UGT1A1 Antibodies) subfamily in a UGT (show SLC35A2 Antibodies) isoform-specific manner.
Polymorphism in UDP-glucuronosyltransferase 1A7 is associated with colorectal cancer.
the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma (Meta-Analysis)
there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.
UGT1A7 variants play a relevant role for pancreas diseases
7-fold increased risk of cancer was observed in smokers with UGT1A7 low activity genotypes. UGT1A7 haplotype carrying C allele (T622C) showed 10-fold increased risk of cancer.
UGT1A7 heterozygosity predicted lower mycophenolic acid (MPA) trough concentrations.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
UDP glucuronosyltransferase 1 family, polypeptide A10
, UDP glucuronosyltransferase 1 family, polypeptide A6
, UDP glucuronosyltransferase 1 family, polypeptide A7
, UDP glucuronosyltransferase 1 family, polypeptide A8
, UDP glucuronosyltransferase 1 family, polypeptide A9
, UDP glycosyltransferase 1 family, polypeptide A6
, UDP-glucuronosyltransferase 1A7
, UDP-glucuronosyltransferase 1-7
, UDP glycosyl transferase 1A7
, UDP glucuronosyltransferase 1 family polypeptide a7 short isoform
, UDP glycosyltransferase 1 family, polypeptide A7
, UDP-glucuronosyltransferase 1 family polypeptide A7s
, UDP-glucuronosyltransferase 1-G
, UDP glucuronosyltransferase 1A7
, UDP-glucuronosyltransferase 1A7C